Accelerated Aging of Functional Brain Networks Supporting Cognitive Function in Psychotic Disorders
Julia M Sheffield1, Baxter P Rogers2, Jennifer U Blackford3
1Department of Psychiatry and Behavioral Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee.
Biological Psychiatry
|February 12, 2019
Summary
Psychotic disorders show accelerated aging in brain networks crucial for cognition, specifically the frontoparietal network (FPN) and cingulo-opercular network (CON). This decline impacts cognitive function, particularly in chronic stages, suggesting early intervention potential.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Science
Background:
- Connectivity in frontoparietal network (FPN) and cingulo-opercular network (CON) declines earliest in healthy aging, impacting cognition.
- Individuals with psychotic disorders often exhibit accelerated biological aging.
- This study investigates accelerated aging in FPN and CON within psychotic disorders.
Purpose of the Study:
- Determine if CON and FPN show accelerated aging in psychotic disorders.
- Confirm associations between network efficiency and cognition.
- Identify if reduced network efficiency is present in early-stage psychosis.
Main Methods:
- Utilized resting-state fMRI and cognitive data from 240 patients with psychosis and 178 healthy controls (HCs).
- Calculated global efficiency (functional integration) for CON, FPN, subcortical, and visual networks.
- Assessed and compared age-related associations and cognitive correlations between groups.
Main Results:
- Significant group-by-age interactions indicated stronger efficiency-age relationships in patients with psychosis for CON and FPN, consistent with accelerated aging.
- Accelerated aging was specific to CON and FPN, not subcortical or visual networks.
- FPN efficiency correlated with cognition; chronic psychosis patients showed significantly lower FPN efficiency than HCs.
Conclusions:
- Functional integration in higher-order cognitive networks is intact in early psychosis.
- Evidence suggests accelerated aging in these networks during psychosis.
- Potential for early intervention targeting cognition in psychosis is highlighted.
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