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Mean Platelet Volume and Platelet Count in Patients with Type 2 Diabetes Mellitus and Impaired Fasting Glucose
Sushama Bhatta1, Samir Singh2, Santosh Gautam3
1Department of Pathology, KIST Medical College, Imadol, Lalitpur, Nepal.
Insights
Mean platelet volume (MPV) is elevated in patients with type 2 diabetes mellitus and impaired fasting glucose, indicating increased thrombotic risk. Platelet count did not differ significantly between groups. This finding suggests MPV may predict vascular complications in diabetes.
Area of Science:
- Endocrinology and Metabolism
- Hematology
- Cardiovascular Research
Background:
- Diabetes mellitus is a chronic metabolic disorder linked to macrovascular and microvascular complications.
- Platelet parameters, including mean platelet volume (MPV) and platelet count, are indicators of thrombotic potential.
- Elevated MPV and platelet count have been observed in diabetic patients, increasing vascular complication risk.
Purpose of the Study:
- To determine MPV and platelet count in patients with Type 2 Diabetes mellitus, impaired fasting glucose, and non-diabetic controls.
- To compare MPV and platelet count across these three groups.
Main Methods:
- A hospital-based, cross-sectional observational study involving 300 participants.
- Participants were categorized into non-diabetic controls, impaired fasting glucose, and Type 2 Diabetes mellitus groups (100 each).
- Statistical analysis included ANOVA with Tukey's post hoc test and Pearson correlation; p<0.05 was significant.
Main Results:
- MPV was significantly higher in diabetic (7.40 ± 0.77 fl) and impaired fasting glucose (6.62 ± 0.58 fl) groups compared to non-diabetic controls (6.06 ± 0.41 fl) (p<0.001).
- No significant difference in platelet count was found between the groups (p=0.869).
- A significant positive correlation was observed between fasting blood sugar and MPV (r=0.559; p<0.001), but not with platelet count (r=0.037; p=0.526).
Conclusions:
- Mean platelet volume is elevated in patients with Type 2 Diabetes mellitus and impaired fasting glucose.
- Elevated MPV in these patient groups suggests increased thrombotic potential.
- MPV serves as a simple, cost-effective biomarker for predicting vascular complications in Type 2 Diabetes mellitus.
Background:
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia and associated with long term macrovascular and microvascular complications. Platelet parameters such as mean platelet volume and platelet count are indicators of thrombotic potential. These parameters have been reported to be increased in diabetic patients, leading to increased risk of vascular complications. The objective of this study was to determine mean platelet volume and platelet count in patients with Type 2 Diabetes mellitus, impaired fasting glucose and non -diabetic controls, and compare mean platelet volume and platelet count between the three groups.
Methods:
A hospital based cross-sectional observational study was conducted at KIST Medical College Teaching Hospital from February to May 2018. A total of 300 participants were included in the study which were grouped into Group 1,2 and 3 based on fasting blood glucose level as non -diabetic controls, impaired fasting glucose and Type 2 Diabetes mellitus respectively with 100 subjects each. Platelet count and mean platelet volume were compared between the three groups. Analysis of variance with post hoc Tukey test and Pearson correlation coefficient were used for statistical evaluation. Data were expressed as mean ± standard deviation. A p value <0.05 was considered as statistically significant.
Results:
Mean platelet volume was significantly higher in diabetic and impaired fasting glucose group (7.40 ± 0.77 fl and 6.62 ± 0.58 fl), respectively as compared to non diabetic group (6.06 ± 0.41 fl) (p<0.001). There was no significant difference in the platelet count between the three groups (p=0.869). Significant correlation was seen between rising fasting blood sugar and mean platelet volume (r =0.559; p<0.001), while no correlation existed between platelet count and fasting blood sugar level (r =0.037; p =0.526).
Conclusions:
Mean platelet volume is increased in patients with type 2 diabetes mellitus and impaired fasting glucose. This is a simple and cost effective test to predict vascular complications in type 2 diabetes mellitus.
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