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Biomaterial-Derived Calcium Carbonate Nanoparticles for Enteric Drug Delivery
Diane Render1, Temesgen Samuel2, Howard King3
1Department Materials Science and Engineering, Tuskegee University, Tuskegee, AL 36088, USA.
Journal of Nanomaterials
|February 12, 2019
Summary
Eggshell-derived calcium carbonate nanoparticles were used to create enteric drug delivery tablets. These novel tablets showed potential for controlled release applications in pharmaceutical development.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Oral drug delivery offers a convenient alternative to parenteral administration.
- Developing effective enteric drug delivery systems remains a key challenge in pharmaceutical formulation.
- Biomaterials offer promising avenues for novel drug delivery applications.
Purpose of the Study:
- To develop an enteric drug delivery system using eggshell-derived calcium carbonate (CaCO3) nanoparticles.
- To fabricate and characterize CaCO3 nanoparticles and incorporate them into tablets.
- To evaluate the enteric delivery potential of the developed tablets.
Main Methods:
- Calcium carbonate (CaCO3) nanoparticles synthesized via top-down ball-milling.
- Nanoparticle characterization using X-ray diffractometry (XRD) and transmission electron microscopy (TEM).
- Tablet formulation with varying CaCO3 core and binder compositions, followed by Eudragit coating.
- In vivo evaluation of enteric delivery in rabbits using radiography.
Main Results:
- CaCO3 nanoparticles were successfully synthesized and characterized.
- Tablets formulated with CaCO3 nanoparticles demonstrated gastric retention for up to 3 hours in rabbits.
- Radiographic imaging confirmed the behavior of the tablets in the gastrointestinal tract.
Conclusions:
- Eggshell-derived CaCO3 nanoparticles are a viable component for enteric drug delivery systems.
- The developed tablet formulations show promise for enteric delivery applications.
- Further optimization of nanoparticle modification and coating can lead to stable, controlled-release pharmaceutical formulations.
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