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Surgical Treatment of Meningiomas - Outcome Associated With Type of Resection, Recurrence, Karnofsky Performance

Robert Sumkovski1, Micun Micunovic2, Ivica Kocevski1

  • 1University Clinic of Neurosurgery, Faculty of Medicine, Ss. Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Open Access Macedonian Journal of Medical Sciences
|February 12, 2019
PubMed
Abstract

Insights

Meningioma recurrence is linked to mitotic count and surgical resection extent. Factors like gender, age, and Karnofsky performance score predict treatment outcomes for these central nervous system tumors.

Area of Science:

  • Neurosurgery
  • Oncology
  • Pathology

Background:

  • Meningiomas are common primary intracranial neoplasms (15-20%) originating from arachnoid membrane cells.
  • Characterized as well-constrained, typically benign, non-infiltrating tumors.
  • Represent a significant area of study within central nervous system oncology.

Purpose of the Study:

  • To evaluate the outcomes of surgically treated meningiomas.
  • To correlate outcomes with Karnofsky performance score, survival, recurrence, surgical excision type, histology, mitotic count, location, and volume.

Main Methods:

  • Retrospective review of 40 operatively treated meningioma patients.
  • Analysis focused on clinical and pathological variables impacting patient outcomes.
  • Statistical correlation of factors like mitotic count, resection extent, and patient survival.

Main Results:

  • A significant association was established between Grade I mitotic count and meningioma regrowth.
  • Mitotic count was verified as a key factor in meningioma recurrence.

Conclusions:

  • Gender, age, and Karnofsky performance score are predictive in meningioma treatment.
  • Extent of surgical resection directly correlates with tumor regrowth.
  • Mitotic count is a significant predictor of meningioma recurrence and impacts patient survival quality and quantity.
Keywords:
KarnofskyMitotic countOutcome of surgically treated meningiomasSimpson

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