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Updated: Jan 29, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
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Cefepime-induced Neurotoxicity: Five Cases Reported in a Single Institution

Kevin Schlidt1, Andrew Kadlec1, Sanjay Bhandari2

  • 1Student, Medical College of Wisconsin, Wauwatosa, USA.

Cureus
|February 12, 2019
PubMed

Insights

Cefepime antibiotic can cause brain issues, known as cefepime-induced encephalopathy (CIE), even in patients with normal kidney function. Early antibiotic discontinuation is key to reducing harm.

Area of Science:

  • Pharmacology
  • Neurology
  • Infectious Diseases

Background:

  • Cefepime, a fourth-generation cephalosporin, is broadly effective against gram-positive and gram-negative bacteria.
  • While generally safe, cefepime can accumulate in patients with impaired renal function, increasing toxicity risk.
  • Cefepime-induced encephalopathy (CIE) is an underreported neurological complication of cefepime toxicity.
Keywords:
cefepimeencephalopathyneurotoxicityrenal failure

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