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Updated: Jan 29, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
Cefepime-induced Neurotoxicity: Five Cases Reported in a Single Institution
Kevin Schlidt1, Andrew Kadlec1, Sanjay Bhandari2
1Student, Medical College of Wisconsin, Wauwatosa, USA.
Cefepime antibiotic can cause brain issues, known as cefepime-induced encephalopathy (CIE), even in patients with normal kidney function. Early antibiotic discontinuation is key to reducing harm.
Area of Science:
- Pharmacology
- Neurology
- Infectious Diseases
Background:
- Cefepime, a fourth-generation cephalosporin, is broadly effective against gram-positive and gram-negative bacteria.
- While generally safe, cefepime can accumulate in patients with impaired renal function, increasing toxicity risk.
- Cefepime-induced encephalopathy (CIE) is an underreported neurological complication of cefepime toxicity.
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