Related Experiment Video

Updated: Jan 29, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.5K

Omalizumab and unmet needs in severe asthma and allergic comorbidities in Japanese children

Sankei Nishima1, Masanari Kozawa2, Ki Lee Milligan2

  • 1National Hospital Organization, Fukuoka National Hospital, Fukuoka, Japan.

Asia Pacific Allergy
|February 12, 2019
PubMed

Insights

Omalizumab, an anti-IgE therapy, is approved for childhood asthma in Japan. This review covers Japanese clinical insights, allergic comorbidities, and future opportunities for this important pediatric asthma treatment.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine

Background:

  • Childhood asthma is a common allergic disease.
  • Omalizumab (anti-IgE therapy) was approved for pediatric asthma in Japan in 2017.
  • Allergic diseases share common pathways and comorbidities.

Purpose of the Study:

  • To review Japanese clinical perspectives on pediatric allergic asthma.
  • To consider allergic comorbidities in pediatric asthma management.
  • To discuss ongoing omalizumab clinical trials and future opportunities.

Main Methods:

  • Literature review of Japanese clinical studies and guidelines.
  • Analysis of omalizumab's role in pediatric allergic asthma.
  • Examination of clinical trial data and future research directions.

Main Results:

  • Omalizumab is an established therapy for pediatric asthma in Japan.
  • Management of allergic comorbidities is crucial for effective asthma control.
  • Ongoing trials are expanding the understanding of omalizumab's efficacy and safety.

Conclusions:

  • Omalizumab offers a valuable treatment option for pediatric allergic asthma in Japan.
  • A comprehensive approach addressing comorbidities is essential.
  • Further research will refine omalizumab's application in pediatric allergy.

Keywords:
BiologicalsJapanOmalizumabPediatric asthmaTherapeutic guidelines

More Related Videos

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique09:37

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

Published on: September 23, 2022

2.2K
Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos05:32

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

9.7K

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
32.3K
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.5K
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.5K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.3K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.1K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.3K