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Related Experiment Video

Updated: Jan 29, 2026

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
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Does the multiple-breath washout test need to be measured before spirometry?

Jacky W Y Au1, Reginald McDonald1, Sanja Stanojevic1

  • 1Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.

ERJ Open Research
|February 12, 2019
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Spirometry testing does not impact short-term multiple-breath washout outcomes. This finding allows for more flexible integration of these lung function tests into clinical practice.

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Area of Science:

  • Pulmonary Function Testing
  • Respiratory Physiology

Background:

  • Multiple-breath washout (MBW) is a sensitive measure of lung aeration and ventilation distribution.
  • Spirometry is a common pulmonary function test used to assess airflow limitation.

Purpose of the Study:

  • To investigate the short-term impact of spirometry on subsequent multiple-breath washout measurements.
  • To determine if performing spirometry before MBW affects MBW outcomes.

Main Methods:

  • A cohort of participants underwent spirometry followed by multiple-breath washout testing.
  • MBW outcomes, including lung clearance index (LCI) and functional residual capacity (FRC), were analyzed.

Main Results:

  • No significant short-term effect of spirometry on key multiple-breath washout parameters was observed.
  • Spirometry did not alter the LCI or FRC in the immediate period post-testing.

Conclusions:

  • Spirometry can be performed immediately before multiple-breath washout without compromising the validity of MBW results.
  • This finding supports greater flexibility in the clinical sequencing of pulmonary function tests.