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A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
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MicroRNA Profile Differences in Neonates at Risk for Cerebral Palsy

S D Chapman1, L Farina2, K Kronforst3

  • 1United States Naval Hospital Okinawa, 18 Medical Group, Kadena Air Base, Okinawa, Japan.

Physical Medicine and Rehabilitation International
|February 12, 2019
PubMed

Insights

Plasma microRNA profiles in at-risk neonates differ based on cerebral palsy risk factors like abnormal tone and intraventricular hemorrhage, showing potential for early CP prediction.

Area of Science:

  • Neonatal research
  • Biomarker discovery
  • Genomics

Background:

  • Cerebral palsy (CP) diagnosis is delayed until 18-24 months.
  • Biomarkers are needed for early CP prediction and therapy assessment.
  • MicroRNAs (miRs) are established disease biomarkers.

Purpose of the Study:

  • To investigate if plasma miR profiles differ in neonates with CP risk factors.
  • To identify potential miR biomarkers for CP prediction.

Main Methods:

  • Cohort study of 31 high-risk neonates (<32 weeks gestation, <1500g).
  • Plasma samples analyzed using locked nucleic acid quantitative real-time PCR (qRT-PCR).
  • miR profiles compared based on presence/absence of intraventricular hemorrhage (IVH) and abnormal tone.

Main Results:

  • Significant differences in plasma miR profiles were observed between neonates with and without IVH.
  • Distinct miR profiles were found in neonates with and without abnormal tone.
  • Greater differences in miR profiles were noted in the abnormal tone comparison versus the IVH comparison.

Conclusions:

  • Plasma miR profiles demonstrate potential as predictive biomarkers for cerebral palsy.
  • This study identified potential miR candidates for future research in CP.
Abstract

Keywords:
BiomarkersCerebral palsyMicroRNAs

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