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Updated: Jan 29, 2026

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest
Published on: April 14, 2023
Personalized physiology-guided resuscitation in highly monitored patients with cardiac arrest-the PERSEUS
Athanasios Chalkias1,2,3, Eleni Arnaoutoglou4, Theodoros Xanthos5
1Faculty of Medicine, Department of Anesthesiology, University of Thessaly, Larisa, Greece. thanoschalkias@yahoo.gr.
Abstract:
Resuscitation guidelines remain uniform across all cardiac arrest patients, focusing on the delivery of chest compressions to a standardized rate and depth and algorithmic vasopressor dosing. However, individualizing resuscitation to the appropriate hemodynamic and ventilatory goals rather than a standard "one-size-fits-all" treatment seems a promising new therapeutic strategy. In this article, we present a new physiology-guided treatment strategy to titrate the resuscitation efforts to patient's physiologic response after cardiac arrest. This approach can be applied during resuscitation attempts in highly monitored patients, such as those in the operating room or the intensive care unit, and could serve as a method for improving tissue perfusion and oxygenation while decreasing post-resuscitation adverse effects.
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