Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

66.0K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
66.0K
Theory of Romantic Attachment in Adulthood03:34

Theory of Romantic Attachment in Adulthood

50.0K
Attachment is a long-standing connection or bond with others. While Attachment Theory was conceived in developmental psychology to describe infant-caregiver bonding, it's been extended into adulthood to include romantic relationships. 
50.0K
Long-term Depression01:05

Long-term Depression

33.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K
Emerging Adulthood01:27

Emerging Adulthood

676
Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
676
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

855
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
855
Freezing Point Depression and Boiling Point Elevation03:12

Freezing Point Depression and Boiling Point Elevation

40.0K
Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
40.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inflammatory biomarkers in complex regional pain syndrome: A systematic review and meta-analysis.

The journal of pain·2026
Same author

Tactile stimulation modulates glucocorticoid receptor and activates the BDNF Cascade in the substantia nigra of haloperidol-treated rats: A sequential investigation into nigrostriatal plasticity.

Progress in neuro-psychopharmacology & biological psychiatry·2025
Same author

7-Nitroindazole, an nNOS inhibitor, reduces migraine-like nociception, demyelination, and anxiety-like behavior in a mouse model of relapsing-remitting multiple sclerosis.

Nitric oxide : biology and chemistry·2025
Same author

Tactile stimulation ameliorates haloperidol-induced movement disturbances in rats by promoting neuromodulation on dopaminergic and glutamatergic systems in nigrostriatal brain area.

Progress in neuro-psychopharmacology & biological psychiatry·2025
Same author

Air Pollution in Relation to COVID-19 Morbidity and Mortality: A Large Population-Based Cohort Study in Catalonia, Spain (COVAIR-CAT).

Research report (Health Effects Institute)·2024
Same author

Targeting TRPV4 Channels for Cancer Pain Relief.

Cancers·2024

Related Experiment Video

Updated: Jan 29, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

22.3K

Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting

Kr Roversi1, Caren Tatiane de David Antoniazzi2, L H Milanesi1

  • 1Centro de Ciências da Saúde Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil.

Molecular Neurobiology
|February 12, 2019
PubMed
Summary
This summary is machine-generated.

Tactile stimulation (TS) effectively reversed depression-like behaviors in adult rats by modulating the HPA axis and neurotrophic factors. This non-pharmacological approach shows promise as a novel therapeutic strategy for neuropsychiatric disorders.

Keywords:
BDNFHandlingHypothalamus-pituitary-adrenal axisReserpine

More Related Videos

The Forced Swim Test as a Model of Depressive-like Behavior
05:42

The Forced Swim Test as a Model of Depressive-like Behavior

Published on: March 2, 2015

39.8K
Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats
08:57

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats

Published on: April 4, 2012

24.3K

Related Experiment Videos

Last Updated: Jan 29, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

22.3K
The Forced Swim Test as a Model of Depressive-like Behavior
05:42

The Forced Swim Test as a Model of Depressive-like Behavior

Published on: March 2, 2015

39.8K
Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats
08:57

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats

Published on: April 4, 2012

24.3K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Animal Models

Background:

  • Depression is a prevalent psychiatric disorder with suboptimal pharmacological treatments.
  • Tactile stimulation (TS) shows potential for neuropsychiatric disorders, but its mechanisms are unclear.
  • Reserpine-induced animal models are used to study depression-like behaviors.

Purpose of the Study:

  • To evaluate the effects of tactile stimulation (TS) on a reserpine-induced depression-like rat model.
  • To investigate the underlying neurobiological mechanisms of TS in depression.

Main Methods:

  • Adult female Wistar rats were administered reserpine to induce depression-like behavior.
  • Rats received tactile stimulation (TS) or were left unhandled.
  • Imipramine served as a positive control.
  • Behavioral tests, hormonal assays, and prefrontal cortex (PFC) analysis were performed.

Main Results:

  • TS reversed depression-like behaviors observed in the forced swimming, splash, and sucrose preference tests.
  • TS normalized reserpine-induced changes in adrenocorticotropic hormone, corticosterone, brain-derived neurotrophic factor (BDNF), and tropomyosin receptor kinase B.
  • TS restored glial fibrillary acidic protein and glucocorticoid receptor levels and increased glial cell line-derived neurotrophic factor in the PFC.

Conclusions:

  • Tactile stimulation (TS) in adulthood exerts beneficial effects on depression-like behaviors.
  • TS modulates the hypothalamic-pituitary-adrenal (HPA) axis and neurotrophic factors more effectively than imipramine.
  • TS represents a potential novel therapeutic strategy for neuropsychiatric disorders, complementing conventional treatments.