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Robust 3D DNA FISH Using Directly Labeled Probes
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Probing the happy place.

Kelly A Mills

    The Journal of Clinical Investigation
    |February 12, 2019
    PubMed
    Summary
    This summary is machine-generated.

    Electrical stimulation of the anterior cingulum bundle reduced anxiety and induced positive effects in epilepsy patients during awake surgery. This approach offers a potential non-sedating method for managing anxiety during neurosurgical procedures.

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    Area of Science:

    • Neurosurgery
    • Neurology
    • Psychiatry

    Background:

    • Awake neurological procedures like deep brain stimulation and craniotomies necessitate patient responsiveness.
    • These procedures can induce significant anxiety and distress, impacting patient tolerance and outcomes.

    Purpose of the Study:

    • To investigate the anxiolytic and mood-modulating effects of electrical stimulation of the left dorsal anterior cingulum bundle.
    • To assess the feasibility of using anterior cingulum stimulation as a non-sedating intervention during awake neurosurgery.

    Main Methods:

    • Three epilepsy patients undergoing intracranial electrode monitoring for surgical planning were included.
    • Electrical stimulation was applied to the left dorsal anterior cingulum bundle while monitoring patient response.

    Main Results:

    • Electrical stimulation of the left dorsal anterior cingulum bundle resulted in a positive, mirthful effect in patients.
    • The stimulation successfully reduced anxiety levels without causing sedation.
    • No adverse effects related to the stimulation were reported.

    Conclusions:

    • Anterior cingulum bundle stimulation shows promise for reducing anxiety during awake neurosurgery.
    • This technique may offer a novel, non-pharmacological approach for managing anxiety in surgical patients.
    • Further research is warranted to explore anterior cingulum stimulation for anxiety disorders.