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Fabricating Paper Based Devices Using Correction Pens.

Naresh Kumar Mani1,2, Anusha Prabhu1, Sujay Kumar Biswas3

  • 1Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.

Scientific Reports
|February 12, 2019
PubMed
Summary
This summary is machine-generated.

This study introduces a fast, low-cost method to create paper-based diagnostic devices using correction pens. This innovation enables accessible point-of-care testing, especially in resource-limited areas.

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Biomedical Engineering

Background:

  • Paper-based analytical devices (PADs) offer a low-cost platform for diagnostics.
  • Fabrication of PADs often requires specialized equipment or multiple steps.
  • There is a need for simple, rapid, and inexpensive methods to produce PADs.

Purpose of the Study:

  • To develop a novel, single-step fabrication method for paper-based devices.
  • To demonstrate the utility of common correction pens for creating flow-controlling regions on paper.
  • To assess the suitability of these fabricated devices for chemical and biological sensing applications.

Main Methods:

  • Utilized standard correction pens to create flow barriers on chromatography paper.
  • Investigated the flow resistance properties of the marked regions to aqueous and organic solvents.
  • Evaluated the preferential fluid flow along the axial direction of the paper channels.

Main Results:

  • Correction pen markings effectively created ubiquitous flow resistances.
  • The method is rapid, taking less than 10 seconds per device.
  • Fabricated devices demonstrated preferential bulk flow along the paper channels.

Conclusions:

  • Correction pens provide a unique, cost-effective tool for fabricating paper-based devices.
  • This simple technique is ideal for developing point-of-care diagnostics in resource-limited settings.
  • The method's simplicity and speed facilitate widespread adoption in low-resource environments.