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Metabolic Pathways Fueling the Endothelial Cell Drive.
Xuri Li1, Anil Kumar1, Peter Carmeliet1,2,3
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China; email: peter.carmeliet@kuleuven.vib.be , lixr6@mail.sysu.edu.cn.
Annual Review of Physiology
|February 12, 2019
Summary
Endothelial cell metabolism is crucial for blood vessel formation and health. Disruptions in these metabolic pathways can lead to vascular diseases, offering potential therapeutic targets.
Area of Science:
- Vascular Biology
- Cell Metabolism
- Biochemistry
Background:
- Endothelial cell (EC) metabolism is vital for vascular health and disease.
- Key metabolic pathways include glycolysis, fatty acid oxidation, and amino acid metabolism.
- These pathways support energy production, biomass synthesis, and redox balance in different EC types.
Purpose of the Study:
- To review current knowledge on EC metabolic pathways.
- To explore the role of EC metabolism in vascular pathologies.
- To discuss therapeutic strategies targeting EC metabolism.
Main Methods:
- Literature review of recent research on EC metabolism.
- Analysis of the link between metabolic dysregulation and vascular diseases.
- Examination of therapeutic implications.
Main Results:
- EC metabolic pathways are essential for vasculature formation.
- Specific roles exist for glycolysis, fatty acid oxidation, and amino acid metabolism in different EC states.
- Metabolic perturbations are linked to EC dysfunction and vascular pathologies.
Conclusions:
- EC metabolism is a critical determinant of vascular health.
- Deregulation of EC metabolism contributes to vascular disease development.
- Targeting EC metabolism presents promising therapeutic avenues for various pathologies.
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