Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

62.0K
Overview
62.0K
Autoimmune Disorders01:29

Autoimmune Disorders

1.7K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.7K
Induced-fit Model01:13

Induced-fit Model

89.1K
Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
89.1K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.0K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.0K
Induced Electric Dipoles01:28

Induced Electric Dipoles

4.8K
A permanent electric dipole orients itself along an external electric field. This rotation can be quantified by defining the potential energy because the external torque does work in rotating it. Then, the potential energy is minimum at the parallel configuration and maximum at the antiparallel configuration. While the former is a stable equilibrium, the latter is an unstable equilibrium.
Since the absolute value of potential energy holds no physical meaning, its zero value can be chosen as per...
4.8K
Induced Electric Fields01:23

Induced Electric Fields

4.6K
The fact that emfs are induced in circuits implies that work is being done on the conduction electrons in the wires. What can possibly be the source of this work? We know that it’s neither a battery nor a magnetic field, as a battery does not have to be present in a circuit where current is induced, and magnetic fields never do any work on moving charges. The source of the work is in fact an electric field that is induced in the wires. For example, if a stationary conductor is placed in a...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Altered Expression of Dual-Specificity Phosphatases in Macrophages Exposed to Lipid Nanoparticles.

FASEB bioAdvances·2026
Same author

Age-related macular degeneration and cerebral amyloid angiopathy have similar pathologies from cholesterol-APOE-amyloid-β-complement mediated inflammation.

Progress in retinal and eye research·2026
Same author

Susceptibility to systemic autoimmunity rather than the presence of the HLA-DR4 peptide binding domain alone leads to severe inflammatory arthritis following inhalation of crystalline silica.

Particle and fibre toxicology·2026
Same author

Reply.

Ophthalmology·2025
Same author

Longitudinal Metabolic Trajectories in Diabetes Prevention Program Participants Reveal Subgroups With Varying Micro- and Macrovascular Complication Risks.

Diabetes care·2025
Same author

Modeling environmental inhalant exposure in rheumatoid arthritis.

Inhalation toxicology·2025

Related Experiment Video

Updated: Jan 29, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

19.9K

Mercury-induced inflammation and autoimmunity.

K Michael Pollard1, David M Cauvi2, Christopher B Toomey3

  • 1Department of Molecular Medicine, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA, 92037, United States of America.

Biochimica Et Biophysica Acta. General Subjects
|February 12, 2019
PubMed
Summary

Mercury exposure can trigger inflammation and autoimmunity in humans and animals. While genetic factors play a role, understanding these pathways could help identify environmentally linked autoimmune conditions.

Keywords:
Animal modelAutoimmunityHumanInflammationMercury

More Related Videos

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
08:17

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

5.6K
A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis
05:44

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis

Published on: December 9, 2022

4.5K

Related Experiment Videos

Last Updated: Jan 29, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

19.9K
Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
08:17

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

5.6K
A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis
05:44

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis

Published on: December 9, 2022

4.5K

Area of Science:

  • Immunology
  • Environmental Health
  • Toxicology

Background:

  • Mercury exposure is linked to immune system pathologies.
  • Epidemiological data on mercury's role in autoimmune diseases is limited.
  • Animal models suggest mercury can contribute to autoimmune disease development.

Purpose of the Study:

  • To review mercury's ability to induce inflammatory and autoimmune responses.
  • To compare these responses in humans and experimental animal models.

Main Methods:

  • Review of existing human and animal studies on mercury exposure and autoimmunity.
  • Analysis of common inflammatory and autoimmune markers.
  • Examination of genetic factors influencing mercury-induced autoimmunity.

Main Results:

  • Similarities in mercury-induced inflammation and autoimmunity observed in humans and animals, including cytokine expression, lymphoproliferation, autoantibody production, and nephropathy.
  • Animal studies highlight strain-dependent genetic regulation of these responses.
  • Many genes involved in mercury-induced autoimmunity are also implicated in idiopathic autoimmune diseases.

Conclusions:

  • Mercury exposure is a likely contributor to the pathogenesis of autoimmunity.
  • Mercury-induced autoimmunity may involve both common and distinct pathways compared to idiopathic autoimmunity.
  • Further research could lead to criteria for identifying environmentally associated autoimmune diseases.