Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Long-patch Base Excision Repair

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:

Patch Clamp

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...

Self-Evaluation: Self-Enhancement and Self-Verification

Self-Evaluation: Self-Enhancement and Self-Verification

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...

Nursing Evaluation

Nursing Evaluation

The evaluation stage signals the end of the nursing process. The nurse gathers evaluative data to assess whether or not the patient has attained the expected results. Whereas the nurse collects data in the nursing assessment to identify the patient's health concerns, the evaluation stage data determines if the indicated health issues are resolved. Evaluative data collection includes two sections: the data acquired to evaluate patient outcomes and the time criteria for data collection.

Self-Evaluation Maintenance Model

Self-Evaluation Maintenance Model

The Self-Evaluation Maintenance (SEM) model offers a psychological framework to understand how individuals’ self-esteem is influenced by the achievements of others, particularly those with whom they share close personal bonds. The SEM model operates when personal rather than social identity guides individuals. Central to this model is the notion that individuals have an inherent desire to preserve a favorable self-image, which is continuously shaped by interpersonal comparisons and...

Dysrhythmias V: Evaluating Dysrhythmias

Dysrhythmias V: Evaluating Dysrhythmias

Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hospitalization for Malignant Arrhythmias Following Initiation of Donepezil: A Retrospective Cohort Study.

Pharmacoepidemiology and drug safety·2026

Same author

Estimating the daily milligrams of morphine equivalent of illicit fentanyl use in Los Angeles: Clinical and epidemiological implications.

Drug and alcohol dependence·2026

Same author

Geographic variation and neighbourhood correlates of mental health-related hospitalizations and emergency department visits in children and youth during the COVID-19 pandemic: a population-based study.

Frontiers in child and adolescent psychiatry·2026

Same author

Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population-Based Study.

Clinical pharmacology and therapeutics·2026

Same author

Estimating the Daily Milligrams of Morphine Equivalent of Illicit Fentanyl Use in Los Angeles: Clinical and Epidemiological Implications.

medRxiv : the preprint server for health sciences·2026

Same author

Association between COVID-19 vaccination and sudden death in apparently healthy younger individuals: A population-based case-control study.

PLoS medicine·2026

Search research articles

Related Experiment Video

Updated: Jan 29, 2026

Evaluation of Synaptic Multiplicity Using Whole-cell Patch-clamp Electrophysiology

Evaluation of Synaptic Multiplicity Using Whole-cell Patch-clamp Electrophysiology

Published on: April 23, 2019

Evaluation of the fentanyl patch-for-patch program in Ontario, Canada.

Mina Tadrous¹, Simon Greaves², Diana Martins²

¹Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada; Institute for Clinical Evaluative Sciences, Toronto, Canada; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.

The International Journal on Drug Policy

|February 12, 2019

Summary

The Patch-for-Patch (P4P) program reduced fentanyl dispensing by 30.5% but did not impact opioid-related hospitalizations or deaths. This opioid strategy shows promise for controlling high-potency fentanyl use.

Keywords:

Drug and narcotic control Fentanyl Government programs Health policy Opioids

More Related Videos

One-channel Cell-attached Patch-clamp Recording

One-channel Cell-attached Patch-clamp Recording

Published on: June 9, 2014

Culturing and Electrophysiology of Cells on NRCC Patch-clamp Chips

Culturing and Electrophysiology of Cells on NRCC Patch-clamp Chips

Published on: February 7, 2012

Related Experiment Videos

Last Updated: Jan 29, 2026

Evaluation of Synaptic Multiplicity Using Whole-cell Patch-clamp Electrophysiology

Evaluation of Synaptic Multiplicity Using Whole-cell Patch-clamp Electrophysiology

Published on: April 23, 2019

One-channel Cell-attached Patch-clamp Recording

One-channel Cell-attached Patch-clamp Recording

Published on: June 9, 2014

Culturing and Electrophysiology of Cells on NRCC Patch-clamp Chips

Culturing and Electrophysiology of Cells on NRCC Patch-clamp Chips

Published on: February 7, 2012

Area of Science:

Public Health
Pharmacology
Health Policy

Background:

Rising prescription opioid use, particularly potent fentanyl, poses a global mortality risk.
The Patch-for-Patch (P4P) program was implemented in Ontario (2012-2015) to reduce fentanyl misuse and diversion.
P4P mandates returning used fentanyl patches before new ones are dispensed.

Purpose of the Study:

To assess the P4P program's effect on fentanyl and non-fentanyl opioid dispensing.
To evaluate the program's impact on opioid-related hospitalizations and mortality.

Main Methods:

A time-series analysis was conducted in Ontario counties using administrative claims data.
Interventional autoregressive integrated moving average (ARIMA) models analyzed outcomes pre- and post-P4P implementation.
Outcomes included monthly dispensing rates, hospital/ED visits for opioid toxicity, and opioid-related deaths.

Main Results:

A 30.5% decrease in fentanyl patch dispensing was observed 24 months post-P4P implementation (p=0.04).
No significant changes were found in non-fentanyl opioid dispensing (p=0.32).
Opioid toxicity hospitalizations (p=0.4) and deaths (p=0.96) showed no significant change within 12 months.

Conclusions:

The P4P program effectively reduced fentanyl patch dispensing without increasing other opioid use.
The program did not demonstrate a measurable impact on opioid toxicity hospital visits or deaths.
P4P programs can be a valuable component of broader opioid control strategies.