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Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
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The endocrine response to severe burn trauma
Federica D'Asta1, Luisella Cianferotti2, Sahil Bhandari3
1a Department of Neuroscience, Psychology, Drug, Research and Child Health, University of Florence, Viale Pieraccini 24, 50139 Florence, Italy.
Expert Review of Endocrinology & Metabolism
|February 13, 2019
Summary
Major burn trauma significantly disrupts the endocrine system, affecting stress response, metabolism, and bone health. Long-term endocrine alterations require appropriate treatment, but evidence-based guidelines are lacking.
Area of Science:
- Endocrinology
- Trauma Medicine
- Metabolic Disorders
Background:
- Major burn trauma induces significant endocrine system alterations.
- These include hypercortisolism, perturbed hypothalamus-hypophysis-target gland axes, and metabolic disturbances.
- Long-term endocrine changes necessitate appropriate management strategies.
Purpose of the Study:
- To highlight the common endocrine alterations following major burn trauma.
- To emphasize the need for diagnosis and correction of these disturbances.
- To underscore the lack of evidence-based guidelines for managing burn-related endocrine issues.
Main Methods:
- Review of endocrine system perturbations post-burn.
- Analysis of metabolic and bone/mineral disturbances.
- Identification of current gaps in clinical guidelines.
Main Results:
- Frequent alterations in endocrine function, including stress response (hypercortisolism).
- Rapid perturbation of multiple hypothalamus-hypophysis-target gland axes.
- Common disturbances in water, glucidic, and bone/mineral metabolism.
- Persistence of endocrine alterations long-term.
Conclusions:
- Burn-related endocrine alterations are common, complex, and persistent.
- Timely diagnosis and correction are crucial for reducing patient morbidity.
- There is a critical need for prospective trials to develop evidence-based recommendations.
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