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Insulin-like growth factor-I receptor signaling and resistance in breast cancer

Helen E Jones1, Julia Mw Gee1, Iain R Hutcheson1

  • 1a Cardiff University, Tenovus Centre for Cancer Research, King Edward VII Avenue, Cardiff CF10 3XF, UK. joneshe1@cardiff.ac.uk.

Expert Review of Endocrinology & Metabolism
|February 13, 2019
PubMed

Insights

Insulin-like growth factor-I receptor (IGF-IR) signaling promotes cancer growth and resistance to therapies. Inhibiting IGF-IR, especially in combination treatments, may prevent cancer progression and overcome drug resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Insulin-like growth factor-I receptor (IGF-IR) signaling is crucial for cancer cell proliferation, survival, and migration.
  • IGF-IR mediates resistance to chemotherapy, radiation, antihormones, and antigrowth factor therapies, including those targeting the erb family.
  • The IGF-IR pathway is clinically prominent in breast cancer, making it a significant therapeutic target.

Purpose of the Study:

  • To review the role of IGF-IR in mediating resistance mechanisms in breast cancer.
  • To discuss combination treatment strategies targeting IGF-IR to overcome resistance.
  • To explore methods for preventing or delaying the development of a resistant cancer phenotype.

Main Methods:

  • Literature review focusing on IGF-IR signaling in cancer.
  • Analysis of emerging data on IGF-IR's role in therapeutic resistance.
  • Discussion of preclinical and clinical strategies for IGF-IR inhibition.

Main Results:

  • IGF-IR signaling contributes to breast cancer cell growth despite antihormone and antigrowth factor treatments.
  • IGF-IR plays a role in acquired resistance to various cancer therapies.
  • Combination regimens targeting IGF-IR show potential for enhanced antitumor effects.

Conclusions:

  • IGF-IR is a critical target for overcoming therapeutic resistance in breast cancer.
  • Combination therapies involving IGF-IR inhibition may prevent or delay the emergence of resistant cancer phenotypes.
  • Targeting IGF-IR is a promising strategy to improve treatment outcomes in breast cancer.
Keywords:
AG1024HER-2Insulin-like growth factor-I receptorbreast cancerepidermal growth factor receptorgefitinibresistance

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