Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Nucleosome Core Particle02:10

The Nucleosome Core Particle

14.4K
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
The paradox
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
14.4K
The Nucleosome Core Particle01:12

The Nucleosome Core Particle

2.4K
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...
2.4K
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

10.8K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.8K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

107.1K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.1K
Statements of the Second Law of Thermodynamics01:15

Statements of the Second Law of Thermodynamics

5.0K
The second law of thermodynamics can be stated in several different ways, and all of them can be shown to imply the others. The Clausius’ statement of the second law of thermodynamics is based on the irreversibility of spontaneous heat flow. It states that heat will not flow from the colder body to the hotter body unless some other process is involved. Additionally, as per the Kelvin’s statement, it is impossible to convert the heat from a single source into work without any other...
5.0K
Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

3.8K
When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reporting of Cohort and Routinely Collected Data in Randomised Controlled Trial Protocols (SPIRIT-ROUTINE): extension checklist with explanation and elaboration.

BMJ (Clinical research ed.)·2026
Same author

Reporting of environmental outcomes in randomised clinical trials: a protocol for a scoping review.

BMJ open·2025
Same author

Protocol for development of SPIRIT and CONSORT extensions for reporting climate and environmental outcomes in randomised trials (SPIRIT-ICE and CONSORT-ICE).

BMJ open·2025
Same author

Assessing 5-year follow-up of core outcome set uptake for Bronchiectasis and Hidradenitis Suppurativa: a review of trial registry entries.

BMJ open·2025
Same author

How professional development can be supported for health and care research methodologists: results of the PROfesSionnal develoPmEnt for Research methodologists (PROSPER) e-Delphi and consensus study.

BMJ open·2024
Same author

PRACTICE: Development of a Core Outcome Set for Trials of Physical Rehabilitation in Critical Illness.

Annals of the American Thoracic Society·2024
Same journal

Evaluation of the effect of a long inspiratory ramp time during pressure-controlled ventilation with volume guarantee: study protocol for a randomized, controlled trial.

Trials·2026
Same journal

Impact of tranexamic acid on early allograft dysfunction following liver transplantation: study design for a prospective randomized controlled trial.

Trials·2026
Same journal

SWAT 116: the effectiveness of an infographic to improve trial recruitment-a randomised study within a trial (SWAT).

Trials·2026
Same journal

Nurse counselors' experiences of recruitment and retention of female sex workers in a HIV vaccine trial: a qualitative study from urban Tanzania.

Trials·2026
Same journal

Treatment of genitourinary syndrome of menopause with fractional COâ‚‚ laser versus fractional microablative radiofrequency: study protocol for a double-blind, randomised, non-inferiority trial.

Trials·2026
Same journal

TaILOR: a randomised trial to compare the clinical and cost-effectiveness of a patient-initiated follow-up (PIFU) strategy compared to standard care pathways in people with inflammatory arthritis: a study protocol.

Trials·2026
See all related articles

Related Experiment Video

Updated: Jan 29, 2026

A Protocol for Collecting and Constructing Soil Core Lysimeters
13:23

A Protocol for Collecting and Constructing Soil Core Lysimeters

Published on: June 6, 2016

12.2K

Core Outcome Set-STAndardised Protocol Items: the COS-STAP Statement.

Jamie J Kirkham1, Sarah Gorst1, Douglas G Altman2

  • 1MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Block F Waterhouse Building, 1-5 Brownlow Street, Liverpool, L69 3GL, UK.

Trials
|February 13, 2019
PubMed
Summary
This summary is machine-generated.

A new checklist, the Core Outcome Set-STAndardised Protocol Items (COS-STAP) Statement, guides the development of core outcome set protocols. This ensures transparency and robustness in research, improving the quality of published studies.

Keywords:
Core outcome setGuidelineProtocol

More Related Videos

Using Learning Outcome Measures to assess Doctoral Nursing Education
10:07

Using Learning Outcome Measures to assess Doctoral Nursing Education

Published on: June 21, 2010

19.5K
Sediment Core Sectioning and Extraction of Pore Waters under Anoxic Conditions
09:21

Sediment Core Sectioning and Extraction of Pore Waters under Anoxic Conditions

Published on: March 7, 2016

9.4K

Related Experiment Videos

Last Updated: Jan 29, 2026

A Protocol for Collecting and Constructing Soil Core Lysimeters
13:23

A Protocol for Collecting and Constructing Soil Core Lysimeters

Published on: June 6, 2016

12.2K
Using Learning Outcome Measures to assess Doctoral Nursing Education
10:07

Using Learning Outcome Measures to assess Doctoral Nursing Education

Published on: June 21, 2010

19.5K
Sediment Core Sectioning and Extraction of Pore Waters under Anoxic Conditions
09:21

Sediment Core Sectioning and Extraction of Pore Waters under Anoxic Conditions

Published on: March 7, 2016

9.4K

Area of Science:

  • Health Research Methodology
  • Clinical Trial Design
  • Evidence Synthesis

Background:

  • Core Outcome Sets (COS) are crucial for standardizing outcome measurement in research.
  • Adoption of COS depends on transparent and robust development methods.
  • A standardized protocol enhances the credibility and usability of COS.

Framework:

  • The COS-STAP Statement provides essential protocol documentation for COS development.
  • It outlines key elements including scope, stakeholder engagement, and consensus processes.
  • Developed using the EQUATOR Network's guideline framework.

Implementation:

  • A Delphi survey with over 150 participants informed the COS-STAP checklist.
  • Stakeholder groups included COS developers, journal editors, and patient representatives.
  • A consensus meeting finalized the 13 essential checklist items.

Implications:

  • Journal editors and peer reviewers can use COS-STAP to assess protocol completeness.
  • The statement promotes high-quality protocol drafting for COS development studies.
  • Enhances the transparency and rigor of core outcome set research.