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Increased amygdala-visual cortex connectivity in youth with persecutory ideation.

Stephanie N DeCross1,2, Amy H Farabaugh1,3, Avram J Holmes4

  • 1Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.

Psychological Medicine
|February 13, 2019
PubMed
Summary

Subclinical delusional beliefs are linked to stronger amygdala-visual cortex connectivity in healthy adults. This suggests altered sensory processing may contribute to psychosis risk across a spectrum of symptom severity.

Keywords:
AmygdalafMRIpersecutory ideationresting-state functional connectivitysubclinical delusionsvisual cortex

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Brain Imaging

Background:

  • Subclinical delusional ideas, like persecutory beliefs, are heritable and linked to increased psychosis risk.
  • These symptoms may represent one end of a psychosis severity continuum.
  • Understanding their neurobiology offers insights into clinical psychosis.

Purpose of the Study:

  • Investigate brain function variations associated with subclinical delusional beliefs.
  • Examine the role of amygdala functional connectivity in these beliefs.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) on 131 young adults.
  • Measured resting-state functional connectivity of the amygdala.
  • Assessed a range of subclinical delusional belief severity.

Main Results:

  • Increased amygdala-visual cortex connectivity in individuals with high delusional beliefs, especially persistent ones.
  • Positive correlation between delusional belief severity/distress and amygdala-visual cortex connectivity.
  • Effects were primarily driven by persecutory beliefs.

Conclusions:

  • Findings support the hypothesis of aberrant threat assignment to sensory stimuli in delusion development.
  • Altered amygdala-visual cortex connectivity may be a marker for psychosis pathophysiology.
  • This marker appears relevant across a continuum of psychosis symptom severity.