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Updated: Jan 29, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
Published on: September 27, 2012
Circadian rhythms of cardiovascular autonomic function: Physiology and clinical implications in neurodegenerative
Francesca Baschieri1, Pietro Cortelli2
1Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
Abstract:
Circadian rhythms of blood pressure and heart rate are regulated by a biological clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus, which modulates the autonomic nervous system activity directed to the heart and blood vessels. Humoral mediators released with periodicity induced by the SCN as well as sleep are also important factors. Disruption of physiological cardiovascular circadian rhythms has important clinical implications, as it is associated with increased morbidity and mortality. In this review, firstly we will give an overview on the neuroanatomic and physiologic aspects of cardiovascular circadian rhythms. Secondly we will examine how to assess them in clinical practice. Finally we will discuss certain neurodegenerative diseases in which there is an alteration of these rhythms, such as Parkinson's disease and Alzheimer's disease.
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