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[Hypopituitarism associated with autoimmune pancreatitis: a case report]
Chisaki Ikeda1, Naohiko Makino1, Yoshiaki Ando1
1Department of Gastroenterology, Faculty of Medicine, Yamagata University.
Summary
Autoimmune pancreatitis (AIP) can cause hypopituitarism, affecting anterior pituitary function. Early pituitary evaluation is crucial before steroid treatment in AIP patients to manage potential hormonal deficiencies.
Area of Science:
- Endocrinology
- Gastroenterology
- Immunology
Background:
- Autoimmune pancreatitis (AIP) is a chronic inflammatory condition.
- Hypopituitarism is a potential complication of AIP.
- Elevated immunoglobulin G4 (IgG4) levels are characteristic of AIP.
Observation:
- A 64-year-old male with AIP presented with pituitary stem tumor on MRI.
- The patient exhibited hypopituitarism with severe growth hormone deficiency.
- Imaging showed a pituitary stem tumor and pancreatic duct narrowing.
Findings:
- Steroid therapy effectively reduced the pituitary lesion.
- Steroid treatment improved anterior pituitary function, including growth hormone secretion.
- The case highlights the link between AIP and hypopituitarism.
Implications:
- Pituitary function assessment is vital before initiating steroid therapy in AIP patients.
- Early diagnosis and management of hypopituitarism can prevent long-term complications.
- This case underscores the systemic autoimmune nature of AIP.
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