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Updated: Jan 29, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Exposure and response prevention for obsessive-compulsive disorder: A review and new directions
Dianne M Hezel1,2, H Blair Simpson1,2
1Anxiety Disorders Clinic, New York State Psychiatric Institute, Columbia University, New York, NY, USA.
Abstract:
Obsessive-compulsive disorder (OCD) is characterized by distressing thoughts and repetitive behaviors that are interfering, time-consuming, and difficult to control. Although OCD was once thought to be untreatable, the last few decades have seen great success in reducing symptoms with exposure and response prevention (ERP), which is now considered to be the first-line psychotherapy for the disorder. Despite these significant therapeutic advances, there remain a number of challenges in treating OCD. In this review, we will describe the theoretical underpinnings and elements of ERP, examine the evidence for its effectiveness, and discuss new directions for enhancing it as a therapy for OCD.
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