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Circular RNA: a novel biomarker and therapeutic target for human cancers

Bo Lei1,2, Zhiqiang Tian3, Weiping Fan2

  • 1Department of Pathophysiology, Third Military Medical University, Chongqing 400038, China.

International Journal of Medical Sciences
|February 13, 2019
PubMed

Insights

Circular RNAs (circRNAs) are linked to various diseases. This review summarizes recent research on tumor-related circRNAs, highlighting their roles in cancer and potential as biomarkers or therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are a novel class of noncoding RNA molecules.
  • circRNAs have been associated with neurological and cardiovascular diseases.
  • Differential expression of circRNAs is observed in various human tumors.

Purpose of the Study:

  • To review recent research on tumor-related circRNAs.
  • To summarize the expression and function of circRNAs in cancer.
  • To discuss the clinical potential of circRNAs in oncology.

Main Methods:

  • Literature review of recent studies on circRNAs in human tumors.
  • Analysis of circRNA expression profiles in different cancer types.
  • Synthesis of functional data regarding circRNAs in cancer pathogenesis and metastasis.

Main Results:

  • circRNAs play regulatory roles in cancer development and metastasis.
  • Specific circRNAs show differential expression across liver, gastric, lung, and colorectal cancers.
  • Evidence suggests circRNAs are involved in tumor pathogenesis.

Conclusions:

  • circRNAs represent promising biomarkers for cancer detection.
  • circRNAs hold potential as therapeutic targets for human tumors.
  • Further research can elucidate the clinical utility of circRNAs in oncology.
Keywords:
biomarkercancercircRNAnoncoding RNAtherapy

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