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Values of fractional exhaled nitric oxide for cough-variant asthma in children with chronic cough

Jing Zhou1, Xianhong Zhao1, Xu Zhang2,3,4

  • 1Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou 215003, China.

Journal of Thoracic Disease
|February 13, 2019
PubMed

Insights

Fractional exhaled nitric oxide (FeNO) is a valuable tool for diagnosing cough-variant asthma (CVA) in children. This test offers high sensitivity and specificity, aiding in accurate diagnosis of chronic cough in pediatric patients.

Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Respiratory Medicine

Background:

  • Chronic cough is a prevalent symptom in pediatric populations.
  • Cough-variant asthma (CVA) is a common cause of persistent cough in children.
  • Accurate diagnosis of CVA is crucial for effective management.

Purpose of the Study:

  • To evaluate the diagnostic utility of fractional exhaled nitric oxide (FeNO) in children with chronic cough.
  • To determine the effectiveness of FeNO measurement in identifying cough-variant asthma (CVA).

Main Methods:

  • Prospective cohort study involving children aged 6-14 years with cough duration exceeding 4 weeks.
  • FeNO measurement, sputum cytology, and pulmonary function tests were performed.
  • Comparison between patients with CVA and healthy controls.

Main Results:

  • FeNO measurement demonstrated high diagnostic accuracy for CVA, with an optimal cutoff of 25 ppb.
  • Sensitivity was 84.0%, specificity 97.1%, positive predictive value 97.5%, and negative predictive value 81.4%.
  • FeNO levels correlated significantly with sputum eosinophil counts and decreased post-treatment.

Conclusions:

  • FeNO measurement is a highly sensitive and specific method for diagnosing CVA in children.
  • FeNO testing can be an excellent tool to aid in the diagnosis of pediatric CVA.
  • This non-invasive test supports the identification of asthma in children presenting with chronic cough.
Abstract

Keywords:
Exhaled nitric oxidechildrenchronic coughcough-variant asthma (CVA)sputum eosinophils

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