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Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test
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Developments in human rabies prophylaxis.

M J Warrell

    Revue Scientifique Et Technique (International Office of Epizootics)
    |February 13, 2019
    PubMed
    Summary
    This summary is machine-generated.

    Rabies is preventable with timely vaccination. A new, cost-effective intradermal rabies vaccine regimen can improve accessibility and reduce deaths from this fatal disease.

    Keywords:
    Dog biteEconomicalIntradermalMultiple-sitePost-exposurePre-exposureRabiesRabies immunoglobulinRabies prophylaxisRabies vaccine

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    Area of Science:

    • Veterinary Medicine
    • Infectious Diseases
    • Public Health

    Background:

    • Rabies is a fatal viral disease, entirely preventable through prompt prophylaxis.
    • Deaths from rabies occur due to failures in post-exposure prophylaxis or lack of pre-exposure vaccination.
    • Barriers to rabies prevention include lack of awareness, cost, and accessibility of vaccines.

    Purpose of the Study:

    • To highlight the importance of rabies prevention and prophylaxis.
    • To discuss challenges associated with current rabies vaccine protocols.
    • To introduce a new, potentially more accessible and economical intradermal (ID) rabies vaccine regimen.

    Main Methods:

    • Review of existing rabies prophylaxis protocols and their limitations.
    • Discussion of a novel one-week, multi-site ID regimen for rabies post-exposure prophylaxis.
    • Inclusion of recent 2018 World Health Organization recommendations for rabies prophylaxis.

    Main Results:

    • Intramuscular rabies vaccine delivery is inefficient.
    • Current low-dose intradermal regimens may not be universally trusted or economical.
    • A new one-week ID regimen using less vaccine could enhance prophylaxis accessibility and reduce costs.

    Conclusions:

    • Effective rabies prevention relies on timely and complete prophylaxis.
    • Improving vaccine accessibility and cost-effectiveness is crucial for global rabies control.
    • The proposed new intradermal regimen offers a promising approach to increase rabies vaccine uptake and prevent deaths.