Related Experiment Video

Updated: Jan 29, 2026

Anti-RDL and Anti-mGlutR1 Receptors Antibody Testing in Honeybee Brain Sections using CRISPR-Cas9
09:25

Anti-RDL and Anti-mGlutR1 Receptors Antibody Testing in Honeybee Brain Sections using CRISPR-Cas9

Published on: January 30, 2020

8.6K

Anti-phospholipase A2 receptor antibody and spontaneous remission in membranous nephropathy

Montserrat Diaz1, Irene Agraz2, Maria Jose Soler2

  • 1Nephrology Department, Hospital Universitari Fundació Puigvert, Universitat Autònoma de Barcelona, Barcelona, Spain.

Clinical Kidney Journal
|February 13, 2019
PubMed

Insights

Antibodies to phospholipase A2 receptor (anti-PLA2R) are key in diagnosing idiopathic membranous nephropathy. Measuring anti-PLA2R levels at diagnosis helps predict the kidney disease

Area of Science:

  • Nephrology
  • Immunology

Background:

  • Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults.
  • Antibodies to phospholipase A2 receptor (anti-PLA2R) are implicated in idiopathic MN.
  • The disease course varies, from remission to end-stage renal disease.

Purpose of the Study:

  • To highlight the prognostic significance of anti-PLA2R antibody levels in idiopathic MN.
  • To update the understanding of anti-PLA2R's role in predicting disease progression.

Main Methods:

  • Review of current literature on idiopathic MN and anti-PLA2R antibodies.
  • Analysis of clinical variables associated with MN progression.

Main Results:

  • Anti-PLA2R antibodies are found in the kidney and circulation of idiopathic MN patients.
  • Proteinuria, sex, age, and renal function influence MN progression.
  • Anti-PLA2R levels are important prognostic markers at diagnosis.

Conclusions:

  • Anti-PLA2R antibody levels are crucial for prognostication in idiopathic MN.
  • Early assessment of anti-PLA2R levels aids in predicting patient outcomes.
Keywords:
anti-phospholipase A2 receptor antibodyend-stage kidney diseasemembranous nephropathyspontaneous remission

More Related Videos

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

943
A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

10.4K

Related Concept Videos

Spontaneity02:21

Spontaneity

A spontaneous process is one that occurs naturally under certain conditions. A nonspontaneous process, on the other hand, will not take place unless it is “driven” by the continual input of energy from an external source. Processes have a natural tendency to occur in one direction under a given set of conditions. Water will naturally flow downhill (spontaneous process), but uphill flow (nonspontaneous process) requires outside intervention such as the use of a pump. Iron exposed to...
29.8K
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.6K
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

Overview
110.8K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
132.0K
Spontaneous and Induced Mutations01:30

Spontaneous and Induced Mutations

Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
2.2K
Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
65.5K