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Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model
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Chagas Cardiomyopathy in Latin America Review

Jefferson Luis Vieira1, Fábio Rocha Fernandes Távora2, Maria Gyslane Vasconcelos Sobral2

  • 1Messejana Heart and Lung Hospital Dr. Carlos Alberto Studart Gomes, Av. Frei Cirilo, 3480 Messejana, Fortaleza, CE, 60.846-190, Brazil. jefvieira@yahoo.com.br.

Current Cardiology Reports
|February 13, 2019
PubMed

Insights

Chagas cardiomyopathy, a growing global concern, presents unique challenges in heart failure management. Mechanical circulatory support shows promise for bridging Chagas patients to heart transplantation, offering better outcomes than in non-Chagas patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Chagas cardiomyopathy is a significant public health issue in Latin America, increasingly prevalent worldwide due to migration.
  • It leads to heart failure and poses a substantial health and economic burden.
  • Understanding its clinical, epidemiological, and treatment aspects is crucial.

Purpose of the Study:

  • To review the clinical and epidemiological features of Chagas cardiomyopathy.
  • To discuss specific treatment principles, including antiparasitic therapy and heart transplantation.
  • To assess the institutional experience with mechanical circulatory support in refractory heart failure due to Chagas cardiomyopathy.

Main Methods:

  • Retrospective analysis of institutional data over a 10-year period.
  • Focus on patients with refractory heart failure caused by Chagas cardiomyopathy.
  • Evaluation of outcomes related to mechanical circulatory support and heart transplantation.

Main Results:

  • Antiparasitic treatment for heart failure in Chagas cardiomyopathy remains controversial.
  • Heart transplantation is an established option for Chagas cardiomyopathy.
  • Mechanical circulatory support in Chagas patients demonstrated more successful bridging to heart transplantation compared to non-Chagas patients.

Conclusions:

  • Chagas patients may have favorable characteristics for mechanical circulatory support in advanced heart failure.
  • Mechanical circulatory support is a viable and effective option for bridging Chagas cardiomyopathy patients to heart transplantation.
  • Further research is needed, but current institutional experience supports its use.
Abstract

Keywords:
AnatomopathologyCardiomyopathyChagas diseaseHeart failureHeart transplantationMechanical circulatory support

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