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Updated: Jan 29, 2026
10:35
Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
Published on: September 20, 2015
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PET imaging in renal cancer.
Liza Lindenberg1, Esther Mena1, Peter L Choyke1
1Molecular Imaging Program, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Current Opinion in Oncology
|February 13, 2019
Summary
Positron emission tomography (PET) imaging shows promise for kidney cancer (RCC) detection and prognosis, especially in metastatic cases. Further research into novel molecular tracers is crucial for advancing diagnostic and therapeutic strategies.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiochemistry
Background:
- Kidney cancer (RCC) is a significant global health concern, with limited efficacy of conventional imaging for detection and staging.
- Functional PET/CT imaging offers potential advantages over anatomic imaging in managing RCC, but its role is still developing.
Purpose of the Study:
- To review the current state and future potential of PET imaging agents in the diagnosis and management of renal cell carcinoma (RCC).
- To highlight recent findings and ongoing research in novel PET radiotracers for RCC.
Main Methods:
- Review of current literature on PET imaging in RCC.
- Analysis of various PET radiotracers, including FDG, CAIX, 89Zr-bevacizumab, 89Zr-gerontuximab, FLT, PSMA, 11C-choline, and NaF.
Main Results:
- 18F-fluorodeoxyglucose (FDG) is a key radiotracer, with CAIX imaging showing utility in clear cell RCC.
- Emerging tracers like 89Zr-bevacizumab and 89Zr-gerontuximab show potential for RCC detection and prognosis.
- Differentiating primary RCC from normal tissue remains challenging for most PET tracers.
Conclusions:
- PET/CT imaging, particularly with FDG, is valuable in the metastatic setting and for monitoring treatment response in RCC.
- Continued investigation of innovative molecular tracers is essential for improving RCC diagnostics and therapeutics.
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