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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

1.7K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.0K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Related Experiment Video

Updated: Jan 29, 2026

Small Bowel Transplantation In Mice
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Demystifying autoimmune small bowel enteropathy.

Luca Elli1, Francesca Ferretti1,2, Valentina Vaira3

  • 1Division of Gastroenterology and Endoscopy, Center for Prevention and Diagnosis of Celiac Disease, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.

Current Opinion in Gastroenterology
|February 13, 2019
PubMed
Summary
This summary is machine-generated.

Autoimmune enteropathy and small-bowel mucosal atrophy are increasingly recognized. This review aids clinicians in diagnosing and managing these challenging conditions, offering insights into therapeutic options and prognosis.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Pathology

Background:

  • Small-bowel disease diagnosis has evolved significantly with advanced enteroscopy and cross-sectional imaging.
  • Small-bowel mucosal atrophy is a frequent finding, presenting diagnostic challenges.
  • Autoimmune enteropathy is an increasingly recognized cause of mucosal atrophy.

Purpose of the Study:

  • To review the current state of autoimmune enteropathy and small-bowel mucosal atrophy.
  • To support clinicians in the diagnosis and management of these conditions.
  • To discuss therapeutic options and prognosis.

Main Methods:

  • Review of current literature on autoimmune enteropathy and small-bowel mucosal atrophy.
  • Analysis of diagnostic markers including serological, endoscopic, histological, and molecular findings.
  • Discussion of therapeutic strategies and prognostic factors.

Main Results:

  • Device-assisted enteroscopy and advanced imaging have improved small-bowel disease diagnosis.
  • Autoimmune enteropathy diagnosis requires integrating multiple markers.
  • The differential diagnosis of small-bowel mucosal atrophy can be complex.

Conclusions:

  • There is a growing body of literature on autoimmune enteropathy and small-bowel atrophy.
  • This review provides practical guidance for clinicians.
  • Accurate diagnosis relies on a comprehensive evaluation of various markers.