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Vitamin E and immune functions.

A Bendich1

  • 1Clinical Nutrition, Hoffmann La Roche Inc., Nutley, NJ 07110.

Basic Life Sciences
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Vitamin E enhances immune function by acting as a key antioxidant. Supplementing diets with vitamin E, and considering interactions with vitamin C and selenium, can improve immune responses, especially when facing challenges like high PUFA intake.

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Area of Science:

  • Immunology and Nutritional Science
  • Antioxidant and Nutrient Interactions

Background:

  • Vitamin E is a crucial lipid-soluble antioxidant in cellular membranes, vital for immune function.
  • Nutritional deficiencies or imbalances in antioxidants like vitamin E, selenium, and vitamin C can impair immune responses.
  • Polyunsaturated fatty acids (PUFAs) can suppress immune function, necessitating protective nutrient strategies.

Purpose of the Study:

  • To investigate the role of vitamin E in immune function.
  • To examine how vitamin E interacts with other nutrients (vitamin C, selenium) and dietary factors (PUFAs) to modulate immune responses.
  • To understand the impact of antioxidant status on overall immune health.

Main Methods:

  • Animal models were fed diets with varying levels of vitamin E, including deficient and supplemented conditions.

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  • The effects of high polyunsaturated fatty acid (PUFA) intake on immune function were assessed.
  • Interactions between vitamin E, vitamin C, and selenium in modulating immune responses were evaluated.

    • Main Results:

    • Vitamin E deficiency significantly impairs immune responses.
    • Supplementation with higher-than-adequate vitamin E levels enhances immune function.
    • Vitamin E partially counteracts the immunosuppressive effects of high PUFA intake and selenium deficiency.
    • Vitamin C may indirectly support vitamin E's immunoenhancing effects by preserving tissue vitamin E levels.

    Conclusions:

    • Dietary antioxidant status, particularly involving vitamin E, profoundly impacts immune function.
    • Nutrient interactions, such as those between vitamin E, vitamin C, and selenium, can synergistically enhance immune defenses.
    • Adequate vitamin E intake is essential for optimal immune performance and can mitigate negative effects of certain dietary components and deficiencies.