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A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures
Published on: July 2, 2014
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The medial temporal lobe in nociception: a meta-analytic and functional connectivity study
Lizbeth J Ayoub1,2,3, Alexander Barnett4, Aziliz Leboucher1
1Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.
Pain
|February 13, 2019
Summary
The right anterior hippocampus (antHC) shows lower activity in chronic pain patients. This brain region also has reduced connectivity to the medial prefrontal cortex in individuals with chronic low-back pain.
Area of Science:
- Neuroscience
- Pain Research
- Medical Imaging
Background:
- The medial temporal lobe (MTL) is increasingly implicated in pain perception and modulation.
- Understanding the specific roles of MTL subregions in chronic pain is crucial for developing targeted therapies.
Purpose of the Study:
- To identify MTL subregions involved in human pain processing.
- To investigate the functional connectivity of the right anterior hippocampus (antHC) in chronic low-back pain (CBP) patients.
Main Methods:
- Two coordinate-based meta-analyses using Activation Likelihood Estimate (ALE) were performed.
- Resting-state functional connectivity analysis of the right antHC was conducted in CBP patients and healthy controls.
Main Results:
- Meta-analysis revealed consistent activation in the right antHC, parahippocampal gyrus, and amygdala in response to experimental pain.
- CBP patients showed significantly reduced activation in the right antHC compared to healthy participants.
- CBP patients exhibited weaker functional connectivity between the right antHC and the medial prefrontal cortex.
Conclusions:
- The right antHC demonstrates altered activity and connectivity in chronic pain states.
- Reduced antHC connectivity to the medial prefrontal cortex may be a key feature of chronic low-back pain.
- Further research is warranted to explore the antHC's role in chronic pain development and management.
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