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Killing of Candida auris by UV-C: Importance of exposure time and distance

Theun de Groot1, Anuradha Chowdhary2, Jacques F Meis1,3,4

  • 1Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital (CWZ), Nijmegen, The Netherlands.

Mycoses
|February 13, 2019
PubMed
Abstract

Insights

Ultraviolet germicidal irradiation (UVGI) effectively kills Candida auris, a dangerous hospital-acquired pathogen. Optimal decontamination requires specific UV-C exposure times and distances, with some C. auris strains showing varied sensitivity.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Environmental Hygiene

Background:

  • Candida auris is an emerging global pathogen causing severe infections, particularly in healthcare settings.
  • This yeast colonizes hospital surfaces and medical devices, contributing to outbreaks.
  • Effective surface decontamination is crucial to prevent the spread of C. auris.

Purpose of the Study:

  • To evaluate the efficacy of UV-C irradiation in killing various strains of Candida auris.
  • To determine the optimal parameters of UV-C exposure time and distance for C. auris decontamination.

Main Methods:

  • Candida auris strains from diverse geographical origins were cultured on glass slides.
  • Samples were exposed to UV-C light for varying durations (5, 10, 20, 30 minutes) at different distances (2 and 4 meters).

Main Results:

  • Maximum killing of C. auris was achieved with 30 minutes of UV-C exposure at 2 meters.
  • Reducing exposure time by half or doubling the distance significantly decreased efficacy (approx. 10-fold and 50-fold, respectively).
  • Geographical origin influenced UV-C susceptibility, with strains from Japan/Korea being more sensitive than those from Venezuela, Spain, and India.

Conclusions:

  • UV-C exposure time and distance are critical factors for effective C. auris killing.
  • Variations in C. auris strains impact susceptibility to UV-C decontamination.
  • Further research is needed to establish the role of UV-C in hospital surface decontamination protocols.
Keywords:
Candida aurisdecontaminationdistanceexposure timeoutbreakultraviolet-Cyeast

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