Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mechanisms of persistent synovitis.

P Merry1, B L Kidd, P I Mapp

  • 1Bone and Joint Unit, London Hospital Medical College, UK.

Scandinavian Journal of Rheumatology. Supplement
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unravelling the mechanisms that determine the uptake and metabolism of magnetic single and multicore nanoparticles in a Xenopus laevis model.

Nanoscale·2017
Same author

Intrapleural blocks for chest wall surgery.

Anaesthesia·2013
Same author

Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement.

Arthritis and rheumatism·2012
Same author

Organic contaminants in groundwater near an underground coal gasification site in northeastern Wyoming.

Environmental science & technology·2012
Same author

Diurnal variation in the salivary melatonin responses to exercise: relation to exercise-mediated tachycardia.

European journal of applied physiology·2011
Same author

Structural and functional connectivity of marine fishes within a semi-enclosed Newfoundland fjord.

Journal of fish biology·2010
Same journal

Abstract of the 35th Scandinavian Congress of Rheumatology, September 20-23, 2014, Stockholm, Sweden.

Scandinavian journal of rheumatology. Supplement·2014
Same journal

Abstracts of the 34th Scandinavian Congress of Rheumatology. Copenhagen, Denmark. September 2-5, 2012.

Scandinavian journal of rheumatology. Supplement·2012
Same journal

How should impaired morning function in rheumatoid arthritis be treated?

Scandinavian journal of rheumatology. Supplement·2011
Same journal

Morning stiffness and other patient-reported outcomes of rheumatoid arthritis in clinical practice.

Scandinavian journal of rheumatology. Supplement·2011
Same journal

How should morning function in rheumatoid arthritis be assessed? Bibliographic study of current assessment.

Scandinavian journal of rheumatology. Supplement·2011
Same journal

How much is a reduction in morning stiffness worth to patients with rheumatoid arthritis?

Scandinavian journal of rheumatology. Supplement·2011
See all related articles

This study explains how rheumatoid arthritis causes symmetrical joint inflammation. Movement sensitizes nerves, releasing substances that promote persistent synovitis and symmetrical joint swelling in rheumatoid arthritis.

Area of Science:

  • Immunology
  • Neuroscience
  • Rheumatology

Background:

  • Rheumatoid arthritis (RA) presents with persistent and symmetrical synovitis.
  • The underlying mechanisms for RA's symmetry and persistence remain incompletely understood.

Purpose of the Study:

  • To propose and support two linked hypotheses explaining the symmetrical and persistent nature of synovitis in rheumatoid arthritis.
  • To elucidate the role of nerve sensitization and neuropeptide release in RA pathogenesis.

Main Methods:

  • Review of clinical and experimental evidence.
  • Hypothetical mechanism detailing nerve sensitization and neuropeptide release.
  • Analysis of movement-induced hypoxic reperfusion injury in joint inflammation.

Related Experiment Videos

Main Results:

  • Proposed mechanism suggests bilateral sensitization of afferent nerve fibers from joints.
  • Movement leads to neuropeptide release, promoting inflammatory responses.
  • Evidence supports movement and hypoxic reperfusion injury as drivers of persistent synovitis in RA.

Conclusions:

  • Nerve sensitization offers a plausible explanation for the symmetrical presentation of synovitis in rheumatoid arthritis.
  • Hypoxic reperfusion injury resulting from movement contributes to the chronicity of synovitis in RA.
  • These findings provide a novel framework for understanding RA pathophysiology.