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Bilateral renal malakoplakia in infancy.

J Wiggelinkhuizen¹, A Mills, M Emms

¹Department of Paediatrics, University of Cape Town, South Africa.

Child Nephrology and Urology

|January 1, 1988

Summary

This study reports a rare case of bilateral renal malakoplakia in infants, a severe kidney disease. Prompt treatment with specific antibiotics and ascorbic acid led to a full recovery, highlighting a potential therapeutic approach.

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Area of Science:

Pediatric Nephrology
Infectious Diseases
Medical Imaging

Background:

Infantile Escherichia coli septicaemia and urinary tract infections can present with persistent fever and renal failure.
Bilateral renal parenchymal malakoplakia is a rare chronic granulomatous disease, previously unreported in infancy.
Defective macrophage bacterial activity, potentially due to low cGMP/cAMP ratio, is implicated in malakoplakia pathogenesis.