Nondipping Pattern and Cardiovascular and Renal Damage in a Population-Based Study (The STANISLAS Cohort Study)

Area of Science:

• Cardiology
• Nephrology
• Hypertension Research

Background:

• The nondipper blood pressure pattern, characterized by an attenuated nocturnal decline, is controversially linked to target organ damage in hypertensive individuals.
• Limited research exists on this association in normotensive populations.

Purpose of the Study:

• To investigate the relationship between the nondipper blood pressure pattern and subclinical cardiovascular and renal damage in a healthy, population-based cohort.

Main Methods:

• Utilized data from 1,334 subjects in the STANISLAS cohort's 4th visit (2011-2016).
• Assessed cardiovascular and renal damage markers including eGFR, albumin/creatinine ratio, pulse wave velocity, central BP, carotid IMT, LV mass, and hypertrophy.
• Defined nondipping status as <10% reduction in systolic or diastolic blood pressure during nighttime via ambulatory blood pressure monitoring (ABPM).

Main Results:

• Included 798 normotensive and 536 hypertensive subjects; 49% overall exhibited the nondipper pattern.
• Mean 24-hour and daytime ABPM measurements were within normal ranges, even for treated hypertensive participants.
• The nondipper pattern showed no association with cardiovascular or renal alterations in this cohort.

Conclusions:

• In a middle-aged population with generally optimal 24-hour blood pressure control, the nondipper pattern did not correlate with increased cardiovascular or renal damage.
• These findings suggest that adequate blood pressure management may attenuate potential risks associated with the nondipper phenomenon.