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Circulating inflammation markers and colorectal adenoma risk
Wen-Yi Huang1, Sonja I Berndt1, Meredith S Shiels1
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Carcinogenesis
|February 13, 2019
Summary
Inflammation drives colorectal cancer. Key markers like CCL20, GRO, and insulin are linked to early adenoma development, offering new insights into colorectal carcinogenesis.
Area of Science:
- Oncology
- Immunology
- Biochemistry
Background:
- Inflammation is recognized as a significant factor in the development of colorectal neoplasia.
- The specific inflammatory pathways involved in the early stages of colorectal carcinogenesis remain incompletely understood.
Purpose of the Study:
- To investigate serum inflammation markers associated with colorectal adenoma risk.
- To identify specific inflammatory processes implicated in early colorectal carcinogenesis.
Main Methods:
- Serum levels of 78 inflammation markers were compared between 171 colorectal adenoma cases and 344 controls.
- Weighted multivariable logistic regression was employed to calculate odds ratios (OR) and 95% confidence intervals (CI).
Main Results:
- Fourteen inflammation markers were associated with overall adenoma risk.
- CC-chemokine ligand 20 (CCL20), growth-related gene oncogene products (GRO), and insulin were significantly associated with both overall and incident adenoma risk.
- CCL20, GRO-related pathways, and insulin show potential roles in early colorectal carcinogenesis.
Conclusions:
- The study provides novel evidence linking CCL20 and GRO-related inflammatory pathways to the early stages of colorectal cancer development.
- Findings support a potential role for insulin in colorectal carcinogenesis.
- Identifying these early inflammatory markers may aid in understanding and potentially preventing colorectal neoplasia.
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