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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
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Despite the strong genetic influence on traits like intelligence, environmental factors significantly shape outcomes. For example, while over 90% of height variation is due to genetic differences, environmental factors such as nutrition also have a notable impact. Similarly, for intelligence, changes in a child's surroundings can significantly alter their IQ. Research shows that enriched environments boost children's academic success and help them develop key cognitive skills. Children...
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Updated: Jan 29, 2026

Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure
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Environmental enteric dysfunction and child stunting.

Sophie Budge1, Alison H Parker1, Paul T Hutchings1

  • 1Cranfield Water Science Institute, Cranfield University, Bedfordshire, United Kingdom.

Nutrition Reviews
|February 13, 2019
PubMed
Summary
This summary is machine-generated.

Environmental enteric dysfunction (EED), an intestinal inflammation, may explain persistent childhood stunting not resolved by diet or hygiene alone. Further research into EED

Keywords:
WASHearly child developmentenvironmental enteric dysfunctionmalnutritionsanitationstunting

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Area of Science:

  • Global child health
  • Pediatric gastroenterology
  • Infectious disease

Background:

  • Childhood stunting affects 23% of children under five globally, with slow reduction rates.
  • Insufficient diet and diarrhea alone do not fully explain persistent growth faltering.
  • Environmental enteric dysfunction (EED), a subclinical intestinal inflammation, is implicated as a key factor.

Purpose of the Study:

  • To review the literature on the proposed pathology and transmission of EED in infants.
  • To explore the link between EED, sanitation, and childhood stunting.
  • To consider improved nutrition and WASH interventions for linear growth.

Main Methods:

  • Literature review of existing studies on EED and childhood stunting.
  • Analysis of proposed causal pathways connecting sanitation, EED, and growth faltering.
  • Synthesis of current understanding of EED pathogenesis and transmission.

Main Results:

  • EED is proposed as an immediate causal factor linking poor sanitation to stunting.
  • Chronic pathogen exposure is a likely cause of EED.
  • Traditional water, sanitation, and hygiene (WASH) interventions may be insufficient to address EED.

Conclusions:

  • EED is a critical area of research for understanding and addressing childhood stunting.
  • Further research is needed to define EED pathogenesis and its precise mechanisms in stunting.
  • Targeted nutrition and WASH strategies addressing EED are necessary for global linear growth improvement.