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Galectin-3 plays an important role in endometriosis development and is a target to endometriosis treatment

Rômulo Medina de Mattos1, Daniel Escorsim Machado2, Jamila Alessandra Perini3

  • 1Morphological Sciences Program, Biomedical Sciences Institute, Federal University of Rio de Janeiro - UFRJ, Rio de Janeiro, RJ, Brazil; University Center IBMR, Laureate Universities, Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Molecular and Cellular Endocrinology
|February 13, 2019
PubMed

Insights

Galectin-3 plays a key role in endometriosis development. Inhibiting galectin-3 (Gal-3) with Gal3C significantly reduced lesion growth and associated markers in experimental endometriosis.

Area of Science:

  • Reproductive biology
  • Immunology
  • Oncology

Background:

  • Endometriosis is a complex gynecological disorder characterized by endometrial tissue outside the uterus.
  • Galectin-3 (Gal-3) is implicated in various biological processes, including inflammation and tissue remodeling, relevant to endometriosis pathogenesis.
  • Understanding the role of Gal-3 in endometriosis is crucial for developing novel therapeutic strategies.

Purpose of the Study:

  • To investigate the role of galectin-3 (Gal-3) in the development of endometriotic lesions.
  • To evaluate the therapeutic potential of recombinant Gal-3 carbohydrate recognition domain (Gal3C) in experimental endometriosis.

Main Methods:

  • Experimental endometriosis was induced in wild-type (WT) and Gal-3 knockout (Gal-3-/-) mice.
  • Lesion analysis included macroscopic, histological, and immunohistochemical assessments.
  • WT mice with endometriosis were treated with Gal3C to assess therapeutic effects.

Main Results:

  • Gal-3 deficiency and Gal3C treatment significantly impaired endometriosis development, reducing lesion implantation and size.
  • Expression of VEGF, VEGFR-2, vascular density, and macrophage distribution were decreased in Gal-3 deficient or inhibited conditions.
  • Gal3C treatment reduced COX-2 and TGFb1 expression, while iNOS and Arginase positive cell distribution differed between knockout and WT mice.

Conclusions:

  • Galectin-3 plays a significant role in the development and progression of endometriosis.
  • Targeting Gal-3 with inhibitors like Gal3C shows therapeutic promise for endometriosis treatment.
Keywords:
AngiogenesisEndometriosisGal3CGalectin-3Therapeutic target

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