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Updated: Jan 29, 2026

Pan-lyssavirus Real Time RT-PCR for Rabies Diagnosis
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Pan-lyssavirus Real Time RT-PCR for Rabies Diagnosis

Published on: July 10, 2019

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Status of antiviral therapeutics against rabies virus and related emerging lyssaviruses

Venice Du Pont1, Richard K Plemper1, Matthias J Schnell2

  • 1Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, United States.

Current Opinion in Virology
|February 13, 2019
PubMed

Insights

Developing new rabies antivirals is crucial due to vaccine limitations and high costs. Targeting the RNA-dependent RNA polymerase offers a promising strategy for broad-spectrum rabies virus inhibitors.

Area of Science:

  • Virology
  • Drug Discovery
  • Public Health

Background:

  • Rabies virus (RABV) causes significant global mortality (60,000 deaths annually).
  • Current vaccines are ineffective post-symptom onset and lack cross-protection against emerging lyssaviruses.
  • Existing prophylaxis requires cold chains and expensive immunoglobulin, highlighting the need for novel antivirals.

Purpose of the Study:

  • To review desirable anti-RABV drug profiles and past research efforts.
  • To explore novel druggable targets for rabies virus based on structural insights.
  • To emphasize the viral RNA-dependent RNA polymerase as a key target for direct-acting antivirals.

Main Methods:

  • Literature review of anti-RABV drug development.
  • Analysis of structural insights into RABV protein organization.
  • Examination of inhibitor candidates and structure-aided drug optimization.

Main Results:

  • Identification of novel druggable targets through advanced structural analysis.
  • Evaluation of past inhibitor candidates and their limitations.
  • Highlighting the viral RNA-dependent RNA polymerase complex as a prime target.

Conclusions:

  • The development of RABV-specific antivirals is urgently needed.
  • Structural biology provides new avenues for identifying and optimizing antiviral drugs.
  • The RNA-dependent RNA polymerase complex presents a promising target for broad-spectrum rabies virus inhibitors.

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