Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Chemical Reactions: Anabolic and Catabolic01:19

Types of Chemical Reactions: Anabolic and Catabolic

19.5K
The first law of thermodynamics holds that energy can neither be created nor destroyed—it can only change form. An organism's essential function is to consume (ingest) energy and molecules in the foods we eat, convert some of it into fuel for movement, sustain our body functions, and build and maintain our body structures. There are two types of reactions that accomplish this: anabolism and catabolism.
Anabolism is the process of combining smaller, simpler molecules into larger, more...
19.5K
Gene Therapy00:59

Gene Therapy

27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
Group Therapy01:26

Group Therapy

429
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
429
Cancer Therapies02:49

Cancer Therapies

10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Behavior Therapy01:22

Behavior Therapy

694
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
694
Drug Therapy01:28

Drug Therapy

287
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
287

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual-Mechanism Aptamer-Drug Complex Overcomes Paclitaxel Resistance in Ovarian Cancer via Structural Constraint and Telomerase Inhibition.

Research (Washington, D.C.)·2026
Same author

Acidosis-associated gene signature defines novel subtypes and dual-target therapeutic candidates in breast cancer.

Journal of translational medicine·2026
Same author

Blocking interaction of sclerostin loop3 with osteoblastic LRP4 counteracts bone loss without increasing arterial stiffness during mechanical unloading.

Journal of orthopaedic translation·2026
Same author

Stability modification of therapeutic aptamers: from biostability bottlenecks to nuclease-resistant construct design.

RSC chemical biology·2026
Same author

DKK1 in Cancer: A Bench-to-Bedside Review of Molecular Mechanisms and Clinical Applications.

Cancers·2026
Same author

Intracellular sclerostin promotes tumor progression and metastasis as a potential therapeutic target in triple-negative breast cancer.

Cell reports. Medicine·2026

Related Experiment Video

Updated: Jan 29, 2026

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

3.5K

Recent developments in bone anabolic therapy for osteoporosis.

Baosheng Guo1, Songlin Peng1, Chao Liang1

  • 1a Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.

Expert Review of Endocrinology & Metabolism
|February 14, 2019
PubMed
Summary

This review explores RNA interference (RNAi) as a novel bone anabolic therapy for osteoporosis. RNAi offers a promising new strategy to promote bone formation, addressing limitations of current osteoporosis treatments.

Keywords:
BMP signalingRNAiWnt signalinganabolic agentsosteoporosis

More Related Videos

Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention
03:56

Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention

Published on: April 26, 2024

1.3K
Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
02:08

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Published on: July 5, 2024

1.5K

Related Experiment Videos

Last Updated: Jan 29, 2026

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

3.5K
Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention
03:56

Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention

Published on: April 26, 2024

1.3K
Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
02:08

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Published on: July 5, 2024

1.5K

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Regenerative Medicine

Background:

  • Osteoporosis is characterized by bone loss and microarchitectural deterioration, increasing fracture risk due to imbalanced bone formation and resorption.
  • Current osteoporosis treatments primarily focus on inhibiting bone resorption, with limited options for promoting bone formation.
  • The recombinant human parathyroid hormone is the only US FDA-approved anabolic agent, used for two-year treatment cycles.

Purpose of the Study:

  • To introduce RNA interference (RNAi) as a novel therapeutic strategy for osteoporosis.
  • To discuss the potential of RNAi in promoting bone formation (anabolic effect).
  • To review the current status and future perspectives of RNAi for osteoporosis treatment.

Main Methods:

  • Literature review of RNA interference strategies for osteoporosis.
  • Analysis of current therapeutic approaches for osteoporosis.
  • Discussion of the mechanism of RNAi in modulating bone metabolism.

Main Results:

  • RNA interference (RNAi) presents a novel approach for bone anabolic therapy.
  • RNAi strategies can potentially target pathways involved in bone formation and resorption.
  • This approach offers a new avenue for treating osteoporosis by promoting bone building.

Conclusions:

  • RNAi technology holds significant promise as a new anabolic therapy for osteoporosis.
  • Further research and development are needed to translate RNAi into clinical practice.
  • RNAi represents a potential paradigm shift in osteoporosis management by focusing on bone regeneration.