Related Experiment Video
Updated: Jan 29, 2026
08:54
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
15.0K
Brain metastases and treatment: multiplying cognitive toxicities
Elise F Nassif1, Alexandre Arsène-Henry1, Youlia M Kirova1
1a Department of Radiotherapy , Institut Curie , Paris , France.
Expert Review of Anticancer Therapy
|February 14, 2019
Summary
Cancer treatments for brain metastases can cause cognitive impairment, significantly impacting quality of life. Tailoring treatments and standardizing assessments are crucial for managing this toxicity.
Area of Science:
- Neuro-oncology
- Cancer Treatment Toxicity
Background:
- Brain metastases affect 30% of cancer patients.
- Cancer treatments, including surgery, radiotherapy, chemotherapy, targeted therapies, immunotherapies, and hormone therapy, are used for CNS disease.
- Cognitive impairment is a common and quality-of-life-limiting toxicity of these treatments.
Purpose of the Study:
- To review the role of various cancer treatments in cognitive decline for patients with brain metastases.
- To discuss pathological and molecular mechanisms underlying treatment-induced cognitive toxicity.
- To explore future directions for mitigating cognitive side effects and refine benefit-risk assessments.
Main Methods:
- Literature review of cancer treatments (surgery, radiotherapy, chemotherapy, targeted therapies, immunotherapies, hormone therapy).
- Analysis of pathological and molecular mechanisms of cognitive impairment.
- Discussion of other causes of cognitive dysfunction in brain metastasis patients.
Main Results:
- Cancer treatments are associated with significant cognitive toxicities.
- Understanding mechanisms and other contributing factors is key to managing cognitive decline.
- Tailored treatment strategies and standardized cognitive assessments are needed.
Conclusions:
- Cumulative cognitive toxicity must be considered alongside survival benefits.
- Personalized treatment approaches are essential for patients with brain metastases.
- Standardized cognitive assessments are necessary to accurately evaluate treatment-related effects.
Related Concept Videos
01:20Design Example: Capacitance Multiplier Circuit
1.5K
In integrated circuit technology, a capacitance multiplier is often utilized to produce a larger capacitance value when a small physical capacitance falls short. This is achieved by a circuit that multiplies capacitance values by a factor of up to 1000, such that a 10-pF capacitor can replicate the performance of a 100-nF capacitor.
The circuit illustrated in Figure 1 below incorporates two op-amps, with the first operating as a voltage follower and the second acting as an inverting amplifier.
The circuit illustrated in Figure 1 below incorporates two op-amps, with the first operating as a voltage follower and the second acting as an inverting amplifier.
1.5K
01:38Cognitive Dissonance
37.5K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
01:27Language and Cognition
797
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
797
01:25Cognitive Therapy
1.0K
Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
1.0K
01:26Toxic Reactions: Overview
2.0K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
2.0K
01:23Cognition and Behavior
369
Social psychology examines the complex interplay between individual mental processes and social interactions. Historically, the field was divided into two domains: social behavior and social cognition. Researchers focusing on social behavior analyzed actions within social contexts, such as conformity, aggression, or cooperation. Meanwhile, social cognition researchers investigated how people perceive, interpret, and mentally represent their social environments. However, modern perspectives no...
369