Endocarditis, Meningitis and Pneumocystis Pneumonia.

Area of Science:

• Cardiology
• Neurology
• Infectious Diseases

Background:

• Infective endocarditis (IE) poses significant morbidity and mortality risks.
• Systemic embolism is a frequent complication, affecting up to 49% of IE patients.
• Embolic events can impact major arteries, limbs, viscera, and the central nervous system.

Purpose of the Study:

• To highlight the variable clinical presentation of infective endocarditis.
• To emphasize the importance of early diagnosis and treatment in preventing embolic complications.
• To report a case of IE presenting with stroke, acute limb ischemia, and meningitis in a patient with acute lymphoblastic leukemia.

Main Methods:

• Case report of a 60-year-old female patient.
• Clinical presentation analysis of endocarditis with multisystemic involvement.
• Review of diagnostic and treatment implications for IE.

Main Results:

• The patient presented with stroke, acute limb ischemia, and meningitis, indicative of IE with systemic embolism.
• Most embolic events associated with IE occur within two weeks of treatment initiation.
• IE can manifest with diverse clinical signs, affecting various organ systems.

Conclusions:

• Infective endocarditis should be suspected in patients with multisystemic involvement, particularly affecting vascular and neurological systems.
• Early diagnosis is critical as treatment reduces embolism risk; echocardiography accessibility and skill should be enhanced.
• A high index of suspicion and low threshold for investigation are essential in at-risk groups due to high mortality.