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Updated: Jan 29, 2026

Phage-Mediated Genetic Manipulation of the Lyme Disease Spirochete Borrelia burgdorferi
Published on: September 28, 2022
Systemic Sarcoidosis Associated with Exposure to Borrelia burgdorferi in a 21-Year-Old Man
Lars van Dee1, Mylene Stehouwer2, Thomas van Bemmel2
1Universitair Medisch Centrum, Utrecht, The Netherlands.
Objective:
Here we describe a rare case of systemic sarcoidosis in a healthy young man with neuroborreliosis as a putative trigger.
Case:
A 21-year-old forestry worker was diagnosed with systemic sarcoidosis involving his lungs, kidneys and skin. Additional diagnostics revealed signs indicative of a recent infection with Borrelia burgdorferi. The patient was treated successfully with prednisolone and antibiotics.
Conclusion:
Sarcoidosis is a multisystem granulomatous disorder of unknown aetiology. This case suggests that an infection with B. burgdorferi, the causal agent of Lyme disease, could act as a trigger for sarcoidosis.
Learning Point:
We should maintain a high index of suspicion for underlying infectious processes like neuroborreliosis in patients with new-onset sarcoidosis before starting immunosuppressive regimens.
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