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Rearing and Double-stranded RNA-mediated Gene Knockdown in the Hide Beetle, Dermestes maculatus
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You Can't Heyde Forever.

Pedro Pires1, Inês Costa1, Alexandra Raposo1

  • 1Internal Medicine Service 1.2, Hospital de São José, Centro Hospitalar Lisboa Central, E.P.E - Lisboa, Portugal.

European Journal of Case Reports in Internal Medicine
|February 14, 2019
PubMed
Summary

Heyde's syndrome, linking aortic stenosis and intestinal bleeding, is likely underdiagnosed. Surgical aortic valve replacement effectively treated a patient with severe aortic stenosis and recurrent gastrointestinal hemorrhage.

Keywords:
Aortic stenosisHeyde’s syndromeacquired von Willebrand diseaseintestinal angiodysplasia

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Area of Science:

  • Cardiology
  • Gastroenterology
  • Hematology

Background:

  • Heyde's syndrome is an association between aortic stenosis and gastrointestinal bleeding due to intestinal angiodysplasia.
  • Acquired von Willebrand disease is a key factor in the bleeding diathesis.
  • This condition is potentially underdiagnosed, especially in elderly populations with common comorbidities.

Purpose of the Study:

  • To present a case illustrating Heyde's syndrome.
  • To emphasize the diagnostic considerations and management of this condition.
  • To highlight the importance of recognizing the link between aortic stenosis and obscure GI bleeding.

Main Methods:

  • Case report of an 82-year-old woman with recurrent intestinal bleeding and severe anemia.
  • Diagnostic workup including investigation of the gastrointestinal source and echocardiography.
  • Surgical intervention for severe aortic stenosis.

Main Results:

  • Ileal angiectasia was identified as the source of gastrointestinal hemorrhage.
  • Severe aortic stenosis was diagnosed and treated with surgical valve replacement.
  • The patient experienced resolution of bleeding episodes and improved functional status post-surgery.

Conclusions:

  • Heyde's syndrome should be considered in patients with bleeding angiectasia.
  • Aortic valve replacement is the definitive treatment for Heyde's syndrome.
  • Multidisciplinary management is essential for optimal patient outcomes.