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Acute Anaemia: A Challenging Diagnosis
Rui Costa1, Catarina de Araújo Faria1, Catarina Sofia Nunes2
1Internal Medicine Department, Hospital São Francisco Xavier, Lisbon, Portugal.
This case study highlights acute anemia in a patient with gastric cancer and G6PD deficiency. Malignancy-associated microangiopathic hemolytic anemia (MAHA) was identified as a paraneoplastic syndrome.
Area of Science:
- Hematology
- Oncology
Background:
- Acute anemia involves decreased red blood cells, hemoglobin, or hematocrit.
- Hemorrhage is the most common cause, but other etiologies exist.
Purpose of the Study:
- To present a case of acute anemia in a patient with glucose-6-phosphate deficiency and gastric cancer.
- To explore the differential diagnosis of anemia in complex cases.
Main Methods:
- Case report of a 42-year-old male patient.
- Clinical observation during hospitalization.
- Peripheral blood smear analysis for schistocytes.
- Consultation with transfusion medicine.
Main Results:
- Patient presented with symptomatic back pain and developed acute anemia.
- Peripheral blood smear showed schistocytes without hyperbilirubinemia or decreased haptoglobin.
- Bone metastatic disease was confirmed.
- Malignancy-associated microangiopathic hemolytic anemia (MAHA) was diagnosed.
Conclusions:
- Consider multiple etiologies for anemia in a single patient.
- Understanding pathophysiological mechanisms is crucial for diagnosing anemia.
- MAHA can manifest as a paraneoplastic syndrome in malignancy.
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