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Anger, hostility and risk of stroke: a meta-analysis of cohort studies

Hanze Chen1, Beidi Zhang2, Weishuang Xue1

  • 1Department of Neurology, The First Affiliated Hospital, China Medical University, Shenyang, China.

Journal of Neurology
|February 14, 2019
PubMed

Insights

Anger and hostility do not increase stroke risk overall. However, higher anger levels are linked to increased stroke risk in individuals with lower socioeconomic status.

Area of Science:

  • Cardiovascular epidemiology
  • Psychosocial factors in health

Background:

  • Inconsistent findings exist regarding the link between anger/hostility and stroke risk.
  • Previous research necessitates a comprehensive evaluation of this association.

Purpose of the Study:

  • To conduct a meta-analysis assessing the relationship between anger and hostility and stroke risk.
  • To clarify the impact of psychosocial factors on cerebrovascular disease.

Main Methods:

  • Systematic literature search of PubMed and Embase databases.
  • Inclusion of cohort studies examining anger, hostility, and stroke incidence.
  • Pooled analysis using a random effects model for heterogeneity.

Main Results:

  • Meta-analysis included 10 studies with 52,277 participants.
  • No significant overall association between anger/hostility and stroke risk (HR 1.08, 95% CI 0.79-1.47).
  • A positive association emerged when excluding high socioeconomic status individuals (HR 1.30, 95% CI 1.06-1.59).

Conclusions:

  • Elevated anger and hostility levels are not generally associated with increased stroke risk.
  • A notable positive association between anger/hostility and stroke risk exists among individuals of lower socioeconomic status.
Abstract

Keywords:
AngerCohort studiesHostilityMeta-analysisStroke

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