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Related Concept Videos

Quantitative Analysis01:12

Quantitative Analysis

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Quantitative analysis is a technique for measuring the amount of specific constituents in a sample. When the sample's composition is unknown, qualitative analysis is performed first to identify its components, which ensures that the correct substances are measured during the quantitative phase.
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Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
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Related Experiment Video

Updated: Jan 29, 2026

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection
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Ectopic spinal calcification associated with diffuse idiopathic skeletal hyperostosis (DISH): A quantitative micro-ct

Dale E Fournier1,2, Chris J D Norley3, Steven I Pollmann3

  • 1Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, Canada.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|February 14, 2019
PubMed
Summary

Diffuse idiopathic skeletal hyperostosis (DISH) shows varied calcification patterns in the spine. Micro-CT imaging reveals heterogeneous morphology and density, suggesting DISH may represent a spectrum of ectopic calcification.

Keywords:
diffuse idiopathic skeletal hyperostosisectopic calcificationintervertebral discmicro-computed tomographyspine

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Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography
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Area of Science:

  • Orthopaedic Research
  • Radiology
  • Spondyloarthropathy

Background:

  • Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory spondyloarthropathy characterized by spinal ligament and entheses calcification.
  • Current diagnosis relies on radiographic criteria for advanced disease, with unknown etiology and pathogenesis.
  • Radiographic assessment of DISH calcifications lacks detailed characterization of their heterogeneity.

Purpose of the Study:

  • To characterize the morphological and density features of spinal calcifications associated with DISH using micro-computed tomographic imaging.
  • To evaluate the heterogeneity of calcifications in human cadaveric vertebral columns meeting DISH criteria.
  • To determine if radiographic criteria for DISH encompass diverse presentations of ectopic spinal calcification.

Main Methods:

  • Micro-computed tomographic (micro-CT) imaging was used to analyze 19 human cadaveric vertebral columns.
  • Vertebral columns were assessed for radiographic criteria of DISH, defined as calcification of four or more contiguous vertebral segments.
  • Calcifications were analyzed for morphology (e.g., horizontal outgrowths, vertical bands, patchy lesions) and density variations.

Main Results:

  • Fifty-three percent of the cohort met DISH radiographic criteria, with calcifications predominantly in the lower thoracic spine (T8-12).
  • Calcifications in the upper thoracic spine showed variable morphology: continuous vertical bands or discontinuous-patchy lesions.
  • Significant heterogeneity in calcification density was observed, ranging from below to exceeding cortical bone density.

Conclusions:

  • The radiographic criteria for DISH encompass heterogeneous presentations of ectopic spinal calcification.
  • Morphology and density variations in spinal calcifications suggest potential stages in DISH progression or distinct pathologies.
  • Further research is needed to understand the implications of this heterogeneity for disease understanding and management.