Related Experiment Video

Updated: Jan 29, 2026

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
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Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

Published on: July 25, 2011

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MSK2 promotes proliferation and tumor formation in squamous cervical cancer via PAX8/RB-E2F1/cyclin A2 axis

Yueli Wu1, Hongmei Li1, Hong Wang1

  • 1Department of Obstetrics and Gynecology, Heze Municipal Hospital, Heze, Shandong, China.

Journal of Cellular Biochemistry
|February 14, 2019
PubMed

Insights

Mitogen- and stress-activated kinase 2 (MSK2) promotes cervical cancer growth by activating the PAX8/RB-E2F1/cyclin A2 pathway. Inhibiting MSK2 suppressed tumor formation, revealing a potential therapeutic target for squamous cell carcinoma.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Cervical cancer involves abnormal cell proliferation and invasion, with unclear underlying mechanisms.
  • Mitogen- and stress-activated kinase 2 (MSK2) is implicated in tumor growth and metastasis across various cancers.

Purpose of the Study:

  • To investigate the role of MSK2 in cervical cancer cell proliferation.
  • To elucidate the signaling pathways involved in MSK2-mediated pathogenesis of squamous cell carcinoma (SCC).

Main Methods:

  • MSK2 expression analysis in cervical cancer cells (in vivo and in vitro).
  • Correlation analysis between MSK2 and paired-box gene 8 (PAX8) expression.
  • MSK2 knockdown experiments to assess effects on PAX8, retinoblastoma protein (RB) phosphorylation, and downstream proliferation factors (E2F1, cyclin A2).

Main Results:

  • MSK2 expression was significantly upregulated in cervical cancer.
  • MSK2 expression positively correlated with PAX8 expression in cervical cancer specimens.
  • MSK2 knockdown inhibited PAX8 and RB phosphorylation, suppressed E2F1 and cyclin A2 expression, and reduced SCC cell proliferation and tumor formation.

Conclusions:

  • MSK2 promotes SCC formation and development.
  • The oncogenic effects of MSK2 are mediated through the PAX8/RB-E2F1/cyclin A2 signaling axis.
  • MSK2 represents a potential therapeutic target for cervical squamous cell carcinoma.
Keywords:
MSK2PAX8RB-E2F1/cyclin A2 axiscell proliferationcervical cancer

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