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Intravenous immunoglobulin treatment: Where do dermatologists stand?
1Department of Dermatology, Yildirim Beyazit University, Medical School, Ankara, Turkey.
Dermatologic Therapy
|February 14, 2019
Summary
Intravenous immunoglobulins (IVIG) offer promising results for various skin conditions, despite limited FDA approval. Further rigorous studies are needed to confirm efficacy in dermatology.
Area of Science:
- Immunology
- Dermatology
Background:
- Intravenous immunoglobulins (IVIG) are derived from pooled human plasma.
- IVIG is increasingly used in dermatology, showing positive outcomes.
- Current evidence largely consists of case reports, lacking robust clinical trials.
Purpose of the Study:
- To review the current use and reported outcomes of IVIG in dermatological diseases.
- To highlight the need for high-quality research in this area.
Main Methods:
- Review of existing literature and case reports on IVIG use in dermatology.
- Analysis of dermatological conditions treated with IVIG.
Main Results:
- IVIG has been used for autoimmune bullous diseases, Stevens-Johnson syndrome, toxic epidermal necrolysis, connective tissue diseases, pyoderma gangrenosum, atopic dermatitis, chronic urticaria, Kawasaki disease, pretibial myxoedema, scleredema, and graft-versus-host disease.
- Anecdotal evidence suggests potential benefits in these conditions.
Conclusions:
- While IVIG shows potential in treating diverse dermatological conditions, robust randomized controlled trials are essential.
- Further research is required to establish definitive efficacy and safety profiles for IVIG in dermatology.
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