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Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
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Changes in thyroid and renal function after bilateral thyroidectomy in cats.

Heather L Covey1, Yu-Mei Chang2, Jonathan Elliott3

  • 1Department of Clinical Science and Services, Small Animal Medicine and Surgery Group, The Royal Veterinary College, Hertfordshire, United Kingdom.

Journal of Veterinary Internal Medicine
|February 14, 2019
PubMed
Summary
This summary is machine-generated.

Thyroid function in cats changes for years after thyroidectomy, with frequent recurrence of hyperthyroidism. Both creatinine and symmetric dimethylarginine (SDMA) are influenced by thyroxine levels, impacting kidney function assessment.

Keywords:
SDMAazotemiafelinehypothyroid

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Area of Science:

  • Veterinary Medicine
  • Endocrinology
  • Nephrology

Background:

  • Thyroidectomy in cats can lead to iatrogenic hypothyroidism, potentially worsening outcomes in those with chronic kidney disease (CKD).
  • Creatinine's utility in assessing renal function is affected by fluctuating thyroxine levels.
  • Limited data exists on symmetric dimethylarginine (SDMA) in cats with altered thyroid status post-surgery.

Purpose of the Study:

  • To evaluate thyroid status stability at 6 months post-thyroidectomy.
  • To determine the association between SDMA and creatinine, and whether total thyroxine (tT4) influences this relationship.

Main Methods:

  • A retrospective study analyzed electronic records of 81 cats undergoing bilateral thyroidectomy.
  • Thyroid hormone concentrations were assessed in 68 cats within 6 months and in 23 cats for over 18 months post-surgery.
  • Generalized estimating equations were used to analyze associations between body weight, tT4, creatinine, and SDMA.

Main Results:

  • Within 6 months, 22% of cats had persistent/recurrent hyperthyroidism and 49% were hypothyroid.
  • Long-term follow-up showed 17% remained hypothyroid, while 44% developed recurrent hyperthyroidism.
  • SDMA and creatinine were linearly associated, but hyperthyroid cats had significantly higher SDMA relative to creatinine.

Conclusions:

  • Cats experience significant thyroid function changes for years after bilateral thyroidectomy, with a high rate of recurrent hyperthyroidism.
  • Thyroxine concentrations impact both SDMA and creatinine levels, a factor that must be considered when assessing renal function in these patients.
  • The influence of thyroxine on these markers is more pronounced in hyperthyroid cats.